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Al-Safsafah (Arabic: الصفصافة) is a town in northwestern Syria, administratively part of the Tartus Governorate, located southeast of Tartus and 13 kilometers north of the border with Lebanon. Nearby localities include Ayn al-Zibdeh and Kafr Fo to the southeast, al-Tulay'i to the east, Buwaydet al-Suwayqat to the northeast, Beit al-Shaykh Yunes to the north, Ayn al-Zarqa to the northwest and al-Hamidiyah to the west. According to the Syria Central Bureau of Statistics, al-Safsafah had a population of 6,011 in the 2004 census. It is the administrative center of the al-Safsafah nahiyah ("sub-district") which contained 19 localities with a collective population of 23,416 in 2004. The inhabitants are predominantly Alawites.
The al-Safsafah subdistrict was detached from the Safita District and transferred to the Tartus District in 1970. During the presidency of Hafez al-Assad (1970-2000), al-Safsafah and the coastal subdistrict center of al-Hamidiyah competed for the role of capital in a newly planned mantiqah ("district") consisting of the Akkar plain of Syria. The initial recommendation by Ministry of Environment, supported by a United Nations development team, was al-Hamidiyah. The town was larger, better equipped with civil service infrastructure and had been slated to be the third international port of Syria. However, it was a largely Sunni Muslim town and possessed little political weight and thus it was less likely for its position as district capital to be approved by the power structure. Al-Safsafah, on the other hand, although smaller and possessing only basic infrastructure, was better connected with the government. Although no new district has yet been created, in 1994 a branch of the Agricultural Bank of Syria was opened in al-Safsafah, which is normally reserved for district capitals.