Alpha-bisabolene synthase
| Alpha-bisabolene synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.3.38 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Alpha-bisabolene synthase (EC 4.2.3.38, bisabolene synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((E)-alpha-bisabolene-forming).[1] This enzyme catalyses the following chemical reaction
- (2E,6E)-farnesyl diphosphate (E)-alpha-bisabolene + diphosphate
This synthase requires a divalent cation cofactor (Mg2+ or, to a lesser extent, Mn2+) to neutralize the negative charge of the diphosphate leaving group.
References
- ^ Bohlmann, J.; Crock, J.; Jetter, R.; Croteau, R. (1998). "Terpenoid-based defenses in conifers: cDNA cloning, characterization, and functional expression of wound-inducible (E)-α-bisabolene synthase from grand fir (Abies grandis)". Proc. Natl. Acad. Sci. USA. 95: 6756–6761. doi:10.1073/pnas.95.12.6756. PMC 22624. PMID 9618485.
External links
- Alpha-bisabolene+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)