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Alpha-humulene synthase

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Alpha-humulene synthase
Identifiers
EC no.4.2.3.104
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Alpha-humulene synthase (EC 4.2.3.104, ZSS1) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (alpha-humulene-forming).[1] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate alpha-humulene + diphosphate

The enzyme from Zingiber zerumbet, shampoo ginger, also gives traces of beta-caryophyllene.

References

  1. ^ Yu, F.; Okamto, S.; Nakasone, K.; Adachi, K.; Matsuda, S.; Harada, H.; Misawa, N.; Utsumi, R. (2008). "Molecular cloning and functional characterization of α-humulene synthase, a possible key enzyme of zerumbone biosynthesis in shampoo ginger (Zingiber zerumbet Smith)". Planta. 227: 1291–1299. doi:10.1007/s00425-008-0700-x. PMID 18273640.