Andrés Santiago (born October 26, 1989) is a professional baseball pitcher in the Chicago Cubs organization.
He was drafted by the Dodgers in the 16th round of the 2007 MLB Draft. He spent four seasons in the rookie leagues, playing in the Gulf Coast League and later the Arizona League. In 2011 he was promoted to the California League where he was 8-5 with a 5.03 ERA for the Rancho Cucamonga Quakes. He was promoted to the AA Chattanooga Lookouts in 2012.
He played for the Puerto Rican National Team in the 2013 World Baseball Classic.
Santiago pitched a no-hitter for the Lookouts against the Tennessee Smokies on August 28, 2014 in the Southern League. That season, he was 6–8 with a 4.47 ERA in 24 starts for the Lookouts.
Santiago signed a minor league deal with the Chicago Cubs on January 10, 2015.