- Niles Harris: a cynical, middle-aged university professor
- Vita Harris: his much younger wife
- Don Tabaha: a brilliant young Native American medical student
- Marion Clay: a wealthy, middle-aged widow
- Salvatore Zappala: Marion's young lover
- Father William Doherty: an elderly, idealistic Catholic priest
Note: Niles and Vita were originally called Niles and Vita Heron but Wilson changed it when it was pointed out that "Vita Heron" sounded too much like "Vita Herring" a brand available at the time.
A nuclear accident has occurred in a remote section of New Mexico, and two couples who had been travelling through the area are forced to stop and seek shelter, while they await further word from the authorities. They find shelter at a small Catholic mission ministering to impoverished local Native Americans.
The first couple consists of a middle-aged professor and his attractive young wife. He is being taken to a sanitarium near Phoenix after a recent nervous breakdown. The professor has become disillusioned with academia, and now likes to rant that education itself is an evil.
The second couple are a wealthy middle-aged widow and her much younger lover, an aspiring tennis pro. Initially, he appears to be merely a toy to her, but it gradually becomes clear that she loves him deeply and is terrified of losing him.
While at the mission, the couples encounter Father Doherty, an elderly priest who runs the mission. Doherty relies heavily on his foster son, Don Tabaha, a young Native American. Doherty wants desperately for Tabaha to stay in New Mexico and continue to work at the mission, but Tabaha wants nothing more than to get away and leave the poverty of New Mexico far behind.
All characters' future plans are put on hold, while they wait to learn whether the nuclear accident can be resolved. If the problem is fixed, they must all make difficult decisions and move on with their lives. If not, they may all die there at the mission.
Angels Fall premiered Off-Broadway at the Circle Repertory Theatre on October 17, 1982 and closed on November 28, 1982. Directed by Marshall W. Mason, the cast featured Barnard Hughes as Father William Doherty and Fritz Weaver as Niles Harris. The role of Father Doherty was written for Barnard Hughes.
Angels Fall premiered on Broadway at the Longacre Theatre on January 18, 1983 in previews, officially on January 22, and closed on March 13, 1983 after 57 performances. Directed by Marshall W. Mason, Scenic Design was by John Lee Beatty, costumes by Jennifer von Mayrhauser, lighting by Dennis Parichy, sound by Chuck London, and original music by Norman L. Berman. The cast featured Fritz Weaver as Professor Niles Harris, Nancy Snyder as Vita Harris, Danton Stone as Don Tabaha, Tanya Berezin as Marion Clay, Brian Tarantina as Salvatore Zappala and Barnard Hughes as Father William Doherty.
The reviewer for the Christian Science Monitor wrote: "Traditional in form, the play involves a contemporary phenomenon: the incidental threats posed by a nuclear age. But it is primarily about individual responsibility, vocation, and personal fulfillment... Although Mr. Wilson's partial resolution of the central conflict seems rather too pat and predictable, the manner in which his characters reveal themselves to one another and the audience is theatrically engaging. Under Mr. Mason's sensitive guidance, the Circle Rep cast responds with winning conviction to the play's comic as well as its more touching moments, to the frequently sharp exchanges, and to the passages of Wilsonian eloquence. 
- "'Angels Fall' LIsting Off-Broadway" lortel.org, accessed September 3, 2015
- Wilson, Lanford. '"Script, Angels Falls, Dramatists Play Service, Inc., 1983, ISBN 0822216248, p. 4
- "'Angels Fall' Listing, 1983" playbillvault.com, accessed September 3, 2015
- Beaufort, John. "An engaging and 'thoughtfully serious' comedy from Lanford Wilson; Angels Fall Play by Lanford Wilson. Directed by Marshall W. Mason." Christian Science Monitor, October 27, 1982
- Rich, Frank (October 18, 1982). "'Angels Fall,' Landford Wilson's Apocalypse". The New York Times. The New York Times Company. Retrieved 2009-01-21.(subscription required)
- "ANGELS FALL by Lanford Wilson". TIME. Time Inc. November 1, 1982. Retrieved 2009-01-21.
- Lawson, Carol (December 17, 1982). "Angels Fall heads for Broadway". Pittsburgh Post-Gazette. p. 27. Retrieved 2009-01-21.