Acetyl hexapeptide-3

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Acetyl hexapeptide-3
Stereo, skeletal formula of acetyl hexapeptide-8
Other names
  • (6S,9S,12S,15S,18S,21S)-21-Acetamido-1-amino-12-(3-amino-3-oxopropyl)-6-carbamoyl-18-(2-carboxyethyl)-9-(3-guanidinopropyl)-1-imino-15-(2-(methylthio)ethyl)-8,11,14,17,20-pentaoxo-2,7,10,13,16,19-hexaazatetracosan-24-oic acid
  • Argireline
3D model (Jmol)
Molar mass 889.00 g·mol−1
Related compounds
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Acetyl hexapeptide-3 or acetyl hexapeptide-8 (sources differ) is a synthetic anti-wrinkle cosmetics ingredient. It is a peptide which is a fragment of SNAP-25, a substrate of Botulinum toxin (Botox). Acetyl hexapeptide-8 is marketed as Argireline by the Barcelona-based research laboratory Lipotec.[1]

Overview and common uses[edit]

Argireline is used in attempts to decrease the visible effects of aging by reducing the deep wrinkles and lines that occur around the forehead and eyes.[1][2]

Chemically, when applied as a solution to specific areas of the face, Argireline inhibits the reactions that cause muscles to move or contract[1] – for example when forming facial expressions such as smiling or frowning.

Cosmetic studies[edit]

Both in vitro (outside a living organism) and in vivo (using a living organism) tests have been carried out on Argireline, but double-blind clinical trials results have not been published.

Safety research[edit]

Argireline has been developed relatively recently and therefore reports on its long-term use have not yet been produced.


Argireline is the hexapeptide with the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2.[1]


  1. ^ a b c d Blanes-Mira, C; et al. (October 2002). "A synthetic hexapeptide (Argireline) with antiwrinkle activity". Int J Cosmet Sci. 24 (5): 303–10. doi:10.1046/j.1467-2494.2002.00153.x. PMID 18498523. 
  2. ^ Ruiz, MA; Clares, B; Morales, ME; Cazalla, S; Gallardo, V (2007). "Preparation and stability of cosmetic formulations with an anti-aging peptide.". Journal of cosmetic science. 58 (2): 157–71. PMID 17520155.