An axon reflex (also referred to as the flare response) is a response brought on by peripheral nerve stimulation. Examples include vasodilation originally described by Lewis as the "hunter's response" or autonomic reaction to loss of body heat in the extremities (also known as "Lewis wave" and "Lewis reaction").
More sophisticated methods of direct observation of the effects of the axon reflex  have been developed as imaging tools and techniques advanced over the last part of the 20th century. These sorts of experimental results suggest a mechanism which would explain how the interaction of neural factors and genetic endowments make some individuals more resistant to cold. The science has helped to improve medical treatment and prevention of cold related skin damage and frostbite injuries.
- Langley, John Newport (1900). "On axon-reflexes in the pre-ganglionic fibres of the sympathetic system". The Journal of Physiology 25 (5): 364–398. doi:10.1113/jphysiol.1900.sp000803.
- "Applications. Peripheral Autonomic Neuropathy and Axon Reflex. Moor Instruments". us.moor.co.uk. Retrieved 2014-05-07.
- Neuroanatomy - Brief review: The axon reflex by Mevlut YAPRAK. Published online 11 March, 2008
- Wårdell, K.; Naver, H. K.; Nilsson, G. E.; Wallin, B. G. (1993). "The cutaneous vascular axon reflex in humans characterized by laser Doppler perfusion imaging.". The Journal of Physiology 460 (460): 185–199. PMC 1175208. PMID 8487191.
- Article in Neuroanatomy
- Definition in the Online Medical Dictionary
- Definition in the Medical Lexicon
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