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B4GALT2

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(Redirected from B4GALT2 (gene))
B4GALT2
Identifiers
AliasesB4GALT2, B4Gal-T2, B4Gal-T3, beta4Gal-T2, beta-1,4-galactosyltransferase 2
External IDsOMIM: 604013; MGI: 1858493; HomoloGene: 2804; GeneCards: B4GALT2; OMA:B4GALT2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030587
NM_001005417
NM_003780

NM_001253381
NM_017377

RefSeq (protein)

NP_001005417
NP_003771
NP_085076

NP_001240310
NP_059073

Location (UCSC)Chr 1: 43.98 – 43.99 MbChr 4: 117.73 – 117.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Beta-1,4-galactosyltransferase 2 is an enzyme that in humans is encoded by the B4GALT2 gene.[5][6][7]

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Two transcript variants encoding the same protein have been found for this gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117411Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028541Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Almeida R, Amado M, David L, Levery SB, Holmes EH, Merkx G, van Kessel AG, Rygaard E, Hassan H, Bennett E, Clausen H (Jan 1998). "A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3". J Biol Chem. 272 (51): 31979–91. doi:10.1074/jbc.272.51.31979. hdl:2066/216416. PMID 9405390.
  6. ^ Lo NW, Shaper JH, Pevsner J, Shaper NL (Aug 1998). "The expanding beta 4-galactosyltransferase gene family: messages from the databanks". Glycobiology. 8 (5): 517–26. doi:10.1093/glycob/8.5.517. PMID 9597550.
  7. ^ a b "Entrez Gene: B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2".
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Further reading

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