BCAM

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BCAM
Protein BCAM PDB 2PET.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBCAM, AU, CD239, LU, MSK19, basal cell adhesion molecule (Lutheran blood group)
External IDsMGI: 1929940 HomoloGene: 21149 GeneCards: BCAM
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for BCAM
Genomic location for BCAM
Band19q13.32Start44,809,059 bp[1]
End44,821,421 bp[1]
RNA expression pattern
PBB GE BCAM 40093 at fs.png

PBB GE BCAM 203009 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005581
NM_001013257

NM_020486

RefSeq (protein)

NP_001013275
NP_005572

NP_065232

Location (UCSC)Chr 19: 44.81 – 44.82 MbChr 7: 19.76 – 19.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Basal cell adhesion molecule is a protein that in humans is encoded by the BCAM gene.[5] BCAM has also recently been designated CD239 (cluster of differentiation 239).

Function[edit]

Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.[5]

Interactions[edit]

BCAM has been shown to interact with Laminin, alpha 5.[6][7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187244 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002980 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: BCAM basal cell adhesion molecule (Lutheran blood group)". 
  6. ^ Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA (2001). "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity". Blood. 97 (1): 312–20. doi:10.1182/blood.v97.1.312. PMID 11133776. 
  7. ^ Kikkawa Y, Moulson CL, Virtanen I, Miner JH (2002). "Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo". J. Biol. Chem. 277 (47): 44864–9. doi:10.1074/jbc.M208731200. PMID 12244066. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.