BCAM

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BCAM
Protein BCAM PDB 2PET.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases BCAM, AU, CD239, LU, MSK19, basal cell adhesion molecule (Lutheran blood group)
External IDs MGI: 1929940 HomoloGene: 21149 GeneCards: 4059
RNA expression pattern
PBB GE BCAM 203009 at tn.png

PBB GE BCAM 40093 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005581
NM_001013257

NM_020486

RefSeq (protein)

NP_001013275.1
NP_005572.2

NP_065232.1

Location (UCSC) Chr 19: 44.81 – 44.82 Mb Chr 7: 19.76 – 19.77 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Basal cell adhesion molecule is a protein that in humans is encoded by the BCAM gene.[3] BCAM has also recently been designated CD239 (cluster of differentiation 239).

Function[edit]

Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.[3]

Interactions[edit]

BCAM has been shown to interact with Laminin, alpha 5.[4][5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: BCAM basal cell adhesion molecule (Lutheran blood group)". 
  4. ^ Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA (2001). "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity". Blood. 97 (1): 312–20. doi:10.1182/blood.v97.1.312. PMID 11133776. 
  5. ^ Kikkawa Y, Moulson CL, Virtanen I, Miner JH (2002). "Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo". J. Biol. Chem. 277 (47): 44864–9. doi:10.1074/jbc.M208731200. PMID 12244066. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.