BCL2-related protein A1

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Protein BCL2A1 PDB 2VM6.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases BCL2A1, ACC-1, ACC-2, ACC1, ACC2, BCL2L5, BFL1, GRS, HBPA1, BCL2 related protein A1
External IDs MGI: 1278325 HomoloGene: 2988 GeneCards: BCL2A1
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for BCL2A1
Genomic location for BCL2A1
Band 15q25.1 Start 79,960,889 bp[1]
End 79,971,446 bp[1]
RNA expression pattern
PBB GE BCL2A1 205681 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 15: 79.96 – 79.97 Mb Chr 9: 88.72 – 88.73 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Bcl-2-related protein A1 is a protein that in humans is encoded by the BCL2A1 gene.[5][6][7]


This gene encodes a member of the bcl2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.[7]

In melanocytic cells BCL2A1 gene expression may be regulated by MITF.[8]


BCL2-related protein A1 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140379 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000099974 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Savitsky K, Sfez S, Tagle DA, Ziv Y, Sartiel A, Collins FS, Shiloh Y, Rotman G (March 1996). "The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species". Hum Mol Genet. 4 (11): 2025–32. doi:10.1093/hmg/4.11.2025. PMID 8589678. 
  6. ^ Akatsuka Y, Nishida T, Kondo E, Miyazaki M, Taji H, Iida H, Tsujimura K, Yazaki M, Naoe T, Morishima Y, Kodera Y, Kuzushima K, Takahashi T (June 2003). "Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens". J Exp Med. 197 (11): 1489–500. doi:10.1084/jem.20021925. PMC 2193899Freely accessible. PMID 12771180. 
  7. ^ a b "Entrez Gene: BCL2A1 BCL2-related protein A1". 
  8. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  9. ^ Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB, Korsmeyer SJ (Aug 15, 1995). "Multiple Bcl-2 family members demonstrate selective dimerizations with Bax". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7834–8. doi:10.1073/pnas.92.17.7834. PMC 41240Freely accessible. PMID 7644501. 
  10. ^ Zhang H, Cowan-Jacob SW, Simonen M, Greenhalf W, Heim J, Meyhack B (2000). "Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells". J. Biol. Chem. 275 (15): 11092–9. doi:10.1074/jbc.275.15.11092. PMID 10753914. 
  11. ^ Bae J, Hsu SY, Leo CP, Zell K, Hsueh AJ (2001). "Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis". Apoptosis. 6 (5): 319–30. doi:10.1023/A:1011319901057. PMID 11483855. 
  12. ^ Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell. 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340. 

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