BLUF domain

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PDB 1x0p EBI.jpg
structure of a cyanobacterial bluf protein, tll0078
Symbol BLUF
Pfam PF04940
InterPro IPR007024

In molecular biology, the BLUF domain (sensors of blue-light using FAD) is a FAD-binding protein domain. They are present in various proteins, primarily from bacteria, for example a BLUF domain is found at the N-terminus of the AppA protein from Rhodobacter sphaeroides. The BLUF domain is involved in sensing blue-light (and possibly redox) using FAD and is similar to the flavin-binding PAS domains and cryptochromes. The predicted secondary structure reveals that the BLUF domain has a novel FAD-binding fold.[1]


  1. ^ Gomelsky M, Klug G (October 2002). "BLUF: a novel FAD-binding domain involved in sensory transduction in microorganisms". Trends Biochem. Sci. 27 (10): 497–500. PMID 12368079. doi:10.1016/s0968-0004(02)02181-3. 

This article incorporates text from the public domain Pfam and InterPro IPR007024