He was the eldest son of Sir John Guise, 1st Baronet (1733–1794), of Highnam Court, whom he succeeded in 1794, inheriting Highnam Court. He also inherited the Gloucestershire estates of Elmore Court, the original seat of the Guise family, and Rendcomb, on the death in 1807 of his cousin Jane Guise, wife of Shute Barrington (1734-1826), Bishop of Durham.
He was educated at Eton College (1791) and at Christ Church, Oxford (1794). In 1801 he was appointed verderer and deputy warden of the Forest of Dean, which office he retained until his death. In 1807 he was appointed Sheriff of the City of Gloucester and in 1813 as Mayor of Gloucester. He was commissioned as a captain in the North Gloucestershire Militia on 8 June 1798, and on 14 April 1809 he was appointed as Lieutenant-Colonel Commandant to raise the new 1st East Gloucestershire Local Militia at Gloucester.
Death and succession
- Kidd, Charles, Debrett's peerage & Baronetage 2015 Edition, London, 2015, p.B355; As displayed above front door of Elmore Court
- Maj Wilfred Joseph Cripps (revised by Capt Hon M.H. Hicks-Beach & Maj B.N. Spraggett), The Royal North Gloucester Militia, 2nd Edn, Cirencester: Wilts & Gloucestershire Standard Printing Works, 1914, pp. 119–20; Appendix A.
- Local Militia: Gloucestershire, at This Re-illuminated School of Mars: Auxiliary forces and other aspects of Albion under Arms in the Great War against France.
- "GUISE, Sir Berkeley William, 2nd Bt. (1775-1834), of Highnam Court, Glos". History of Parliament Online. Retrieved 9 March 2013.