Beta-amyrin synthase
| Beta-amyrin synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.4.99.39 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Beta-amyrin synthase (EC 5.4.99.39, 2,3-oxidosqualene beta-amyrin cyclase, AsbAS1, BPY, EtAS, GgbAS1, LjAMY1, MtAMY1, PNY, BgbAS) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, beta-amyrin-forming).[1][2][3][4][5][6][7][8][9][10][11] This enzyme catalyses the following chemical reaction
- (3S)-2,3-epoxy-2,3-dihydrosqualene beta-amyrin
Some organism possess a monofunctional beta-amyrin synthase.
References
- ^ Abe, I; Ebizuka, Y.; Seo, S.; Sankawa, U. (1989). "Purification of squalene-2,3-epoxide cyclases from cell suspension cultures of Rabdosia japonica Hara". FEBS Lett. 249: 100–104. doi:10.1016/0014-5793(89)80024-9.
- ^ Abe, I.; Sankawa, U.; Ebizuka, Y. (1989). "Purification of 2,3-oxdosqualene:β-amyrin cyclase from pea seedlings". Chem. Pharm. Bull. 37: 536-. doi:10.1248/cpb.37.536.
- ^ Kushiro, T.; Shibuya, M.; Ebizuka, Y. (1998). "β-Amyrin synthase-cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants". Eur. J. Biochem. 256: 238–244. doi:10.1046/j.1432-1327.1998.2560238.x. PMID 9746369.
- ^ Hayashi, H.; Huang, P.; Kirakosyan, A.; Inoue, K.; Hiraoka, N.; Ikeshiro, Y.; Kushiro, T.; Shibuya, M.; Ebizuka, Y. (2001). "Cloning and characterization of a cDNA encoding β-amyrin synthase involved in glycyrrhizin and soyasaponin biosyntheses in licorice". Biol. Pharm. Bull. 24: 912–916. doi:10.1248/bpb.24.912. PMID 11510484.
- ^ Husselstein-Muller, T.; Schaller, H.; Benveniste, P. (2001). "Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana". Plant Mol. Biol. 45: 75–92. doi:10.1023/A:1006476123930. PMID 11247608.
- ^ Iturbe-Ormaetxe, I.; Haralampidis, K.; Papadopoulou, K.; Osbourn, A.E. (2003). "Molecular cloning and characterization of triterpene synthases from Medicago truncatula and Lotus japonicus". Plant Mol. Biol. 51: 731–743. doi:10.1023/a:1022519709298. PMID 12683345.
- ^ Zhang, H.; Shibuya, M.; Yokota, S.; Ebizuka, Y. (2003). "Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants". Biol. Pharm. Bull. 26: 642–650. doi:10.1248/bpb.26.642. PMID 12736505.
- ^ Hayashi, H.; Huang, P.; Takada, S.; Obinata, M.; Inoue, K.; Shibuya, M.; Ebizuka, Y. (2004). "Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra". Biol. Pharm. Bull. 27: 1086–1092. doi:10.1248/bpb.27.1086. PMID 15256745.
- ^ Kajikawa, M.; Yamato, K.T.; Fukuzawa, H.; Sakai, Y.; Uchida, H.; Ohyama, K. (2005). "Cloning and characterization of a cDNA encoding β-amyrin synthase from petroleum plant Euphorbia tirucalli L". Phytochemistry. 66: 1759–1766. doi:10.1016/j.phytochem.2005.05.021. PMID 16005035.
- ^ Basyuni, M.; Oku, H.; Tsujimoto, E.; Kinjo, K.; Baba, S.; Takara, K. (2007). "Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae". FEBS J. 274: 5028–5042. doi:10.1111/j.1742-4658.2007.06025.x. PMID 17803686.
- ^ Liu, Y.; Cai, Y.; Zhao, Z.; Wang, J.; Li, J.; Xin, W.; Xia, G.; Xiang, F. (2009). "Cloning and functional analysis of a β-amyrin synthase gene associated with oleanolic acid biosynthesis in Gentiana straminea MAXIM". Biol. Pharm. Bull. 32: 818–824. doi:10.1248/bpb.32.818. PMID 19420748.
External links
- Beta-amyrin+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)