Beta defensin 1

DEFB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E4S, 1IJU, 1IJV, 1KJ5, 2NLB, 2NLC, 2NLD, 2NLE, 2NLF, 2NLG, 2NLH, 2NLP, 2NLQ, 2NLS, 2PLZ
Identifiers
Aliases	DEFB1, BD1, DEFB-1, DEFB101, HBD1, defensin beta 1
External IDs	OMIM: 602056; MGI: 1096878; HomoloGene: 88476; GeneCards: DEFB1; OMA:DEFB1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	6,877,936 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	22,285,201 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; salivary gland; ; skin of abdomen; ; minor salivary glands; ; human kidney; ; skin of leg; ; islet of Langerhans; ; mucosa of esophagus; ; olfactory zone of nasal mucosa; ; right lobe of liver;
	Top expressed in
	conjunctival fornix; ; right kidney; ; human kidney; ; islet of Langerhans; ; lip; ; cornea; ; esophagus; ; skin of external ear; ; corneal stroma; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	CCR6 chemokine receptor binding; protein binding; identical protein binding;
Cellular component	Golgi lumen; extracellular region; extracellular exosome; sperm midpiece; extracellular space; extrinsic component of membrane; microvesicle; membrane;
Biological process	chemotaxis; G protein-coupled receptor signaling pathway; defense response; innate immune response in mucosa; acute inflammatory response; response to bacterium; immune response; response to testosterone; positive regulation of flagellated sperm motility involved in capacitation; defense response to bacterium; calcium-mediated signaling using intracellular calcium source; cAMP-mediated signaling; defense response to Gram-negative bacterium; antimicrobial humoral response; innate immune response; antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium;
	Sources:Amigo / QuickGO
Orthologs
	1672
	13214
	ENSG00000164825; ENSG00000284881
	ENSMUSG00000044748
	P60022
	P56386
	NM_005218
	NM_007843
	NP_005209
	NP_031869
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-defensin 1 is a protein that in humans is encoded by the DEFB1 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c ENSG00000284881 GRCh38: Ensembl release 89: ENSG00000164825, ENSG00000284881 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044748 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bensch KW, Raida M, Magert HJ, Schulz-Knappe P, Forssmann WG (Sep 1995). "hBD-1: a novel beta-defensin from human plasma". FEBS Lett. 368 (2): 331–5. doi:10.1016/0014-5793(95)00687-5. PMID 7628632.
^ "Entrez Gene: DEFB1 defensin, beta 1".

References

Further reading