Although the term has occasionally been used in other ways, in medical literature biotrauma is usually defined as a severe inflammatory response produced in the lungs of patients who breathe by means of a mechanical ventilator for a long period of time. The term was coined in a 1998 paper by L. N. Tremblay and A. S. Slutsky, titled Ventilator-induced injury: from barotrauma to biotrauma. The message of that paper was that barotrauma caused by pressure differentials is only one of several types of lung damage that a ventilator can produce.
^Halbertsma FJ, Vaneker M, Scheffer GJ, van der Hoeven JG (2005). "Cytokines and biotrauma in ventilator-induced lung injury: a critical review of the literature". Neth J Med. 63 (10): 382–92. PMID16301759.
^Tremblay LN, Slutsky AS (1998). "Ventilator-induced injury: from barotrauma to biotrauma". Proc Assoc Am Physicians. 110 (6): 482–8. PMID9824530.