Björn Dahlbäck
Björn Dahlbäck (born 1949) is a Swedish physician, medical researcher, and professor of clinical chemistry, specializing in hematology and the molecular mechanisms of blood coagulation.[1] He determined that activated protein C (APC) resistance is the most common inherited risk factor of venous thrombosis.
Education and career
[edit]Dahlbäck graduated with an M.D. from Lund University and then completed his medical internship and residency at Malmö's University Hospital,[2] which is now merged into Skåne University Hospital. In 1981 he received from Lund University his doctorate with dissertation The activation of prothrombin on the platelet surface[3] under the supervision of Johan Stenflo. Dahlbäck was a postdoc at La Jolla's Scripps Research, where his supervisor was Hans J. Müller-Eberhard, and later was a visiting scholar at Oklahoma Medical Research Foundation (OMRF). In 1989 at Lund University, Dahlbäck was appointed a full professor of clinical chemistry, specializing in hematology and cardiac and cardiovascular systems.[2][1] He is also the director of the blood coagulation unit at Malmö General Hospital.[4]
His research was important in showing that APC resistance is caused by a harmful mutation in the F5 gene corresponding to the protein Factor V; the specific mutation was subsequently identified by several groups of researchers and is now called Factor V Leiden.[2] In 2013, Dahlbäck and colleagues identified the F5 gene mutation that causes the phenotype called "east Texas bleeding disorder".[5][2]
He has received several honors and awards,[2] including in 1996 the Louis-Jeantet Prize for Medicine[4] and in 2019 H. M. The King's Medal (H.M. Konungens Medalj) of the 12th size from the Royal Court of Sweden.[6] He is a member of the Royal Swedish Academy of Sciences.[7]
In 2000, Academic Press published Hematology: Landmark Papers of the Twentieth Century , which included the 1994 paper Resistance to activated protein C as a basis for venous thrombosis by Peter J. Svensson and Björn Dahlbäck.[8][9]
Selected publications
[edit]- Dahlback, B.; Stenflo, J. (1981). "High molecular weight complex in human plasma between vitamin K-dependent protein S and complement component C4b-binding protein". Proceedings of the National Academy of Sciences. 78 (4): 2512–2516. Bibcode:1981PNAS...78.2512D. doi:10.1073/pnas.78.4.2512. PMC 319377. PMID 6454142.
- Suzuki, K.; Dahlbäck, B.; Stenflo, J. (1982). "Thrombin-catalyzed activation of human coagulation factor V". Journal of Biological Chemistry. 257 (11): 6556–6564. doi:10.1016/S0021-9258(20)65178-X. PMID 7076681.
- Suzuki, K.; Stenflo, J.; Dahlbäck, B.; Teodorsson, B. (1983). "Inactivation of human coagulation factor V by activated protein C". Journal of Biological Chemistry. 258 (3): 1914–1920. doi:10.1016/S0021-9258(18)33076-X. PMID 6687387.
- Dahlbäck, Björn (1991). "Protein S and C4b-Binding Protein: Components Involved in the Regulation of the Protein C Anticoagulant System". Thrombosis and Haemostasis. 66 (1): 049–061. doi:10.1055/s-0038-1646373. PMID 1833851. S2CID 24929072.
- Dahlback, B.; Carlsson, M.; Svensson, P. J. (1993). "Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C". Proceedings of the National Academy of Sciences. 90 (3): 1004–1008. Bibcode:1993PNAS...90.1004D. doi:10.1073/pnas.90.3.1004. PMC 45799. PMID 8430067.
- Zöller, B.; Svensson, P. J.; He, X.; Dahlbäck, B. (1994). "Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C". Journal of Clinical Investigation. 94 (6): 2521–2524. doi:10.1172/JCI117623. PMC 330087. PMID 7989612.
- Dahlback, B.; Hildebrand, B. (1994). "Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor V". Proceedings of the National Academy of Sciences. 91 (4): 1396–1400. Bibcode:1994PNAS...91.1396D. doi:10.1073/pnas.91.4.1396. PMC 43165. PMID 8108421.
- Zöller, B.; Dahlbäck, B. (1994). "Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis". The Lancet. 343 (8912): 1536–1538. doi:10.1016/S0140-6736(94)92940-8. PMID 7911873. S2CID 34764295.
- Shen, L.; Dahlbäck, B. (1994). "Factor V and protein S as synergistic cofactors to activated protein C in degradation of factor VIIIa". Journal of Biological Chemistry. 269 (29): 18735–18738. doi:10.1016/S0021-9258(17)32228-7. PMID 8034625.
- Dahlbäck, Björn (1995). "The protein C anticoagulant system: Inherited defects as basis for venous thrombosis". Thrombosis Research. 77 (1): 1–43. doi:10.1016/0049-3848(94)00138-4. PMID 7701473.
- Lane, David A.; Mannucci, Pier M.; Bauer, Kenneth A.; Bertina, Rogier M.; Bochkov, Nikolay P.; Boulyjenkov, Victor; Chandy, Mammen; Dahlbäck, Björn; Ginter, E. K.; Miletich, Joseph P.; Rosendaal, Frits R.; Seligsohn, Uri (1996). "Inherited Thrombophilia*: Part 2". Thrombosis and Haemostasis. 76 (6): 0824–0834. doi:10.1055/s-0038-1650673. S2CID 15544852.
- Lindqvist, P.; Dahlbäck, B.; Marŝál, K. (1999). "Thrombotic risk during pregnancy: A population study". Obstetrics & Gynecology. 94 (4): 595–599. doi:10.1016/S0029-7844(99)00308-7. PMID 10511366.
- Xu, Ning; Dahlbäck, Björn (1999). "A Novel Human Apolipoprotein (ApoM)". Journal of Biological Chemistry. 274 (44): 31286–31290. doi:10.1074/jbc.274.44.31286. PMID 10531326.
- Dahlbäck, Björn (2000). "Blood coagulation". The Lancet. 355 (9215): 1627–1632. doi:10.1016/S0140-6736(00)02225-X. PMID 10821379. S2CID 31246121.
- Angelillo-Scherrer, Anne; De Frutos, Pablo Garcia; Aparicio, Cristina; Melis, Els; Savi, Pierre; Lupu, Florea; Arnout, Jef; Dewerchin, Mieke; Hoylaerts, Marc F.; Herbert, Jean-Marc; Collen, Désiré; Dahlbäck, Björn; Carmeliet, Peter (2001). "Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis". Nature Medicine. 7 (2): 215–221. doi:10.1038/84667. PMID 11175853. S2CID 10502090.
- Nicolaes, Gerry A.F.; DahlbäCk, Björn (2002). "Factor V and Thrombotic Disease". Arteriosclerosis, Thrombosis, and Vascular Biology. 22 (4): 530–538. doi:10.1161/01.ATV.0000012665.51263.B7. PMID 11950687. S2CID 13215200.
- Blom, Anna M.; Villoutreix, Bruno O.; Dahlbäck, Björn (2004). "Complement inhibitor C4b-binding protein—friend or foe in the innate immune system?". Molecular Immunology. 40 (18): 1333–1346. doi:10.1016/j.molimm.2003.12.002. PMID 15072852.
- Dahlbäck, Björn; Villoutreix, Bruno O. (2005). "The anticoagulant protein C pathway". FEBS Letters. 579 (15): 3310–3316. doi:10.1016/j.febslet.2005.03.001. PMID 15943976. S2CID 38782845.
- Hafizi, Sassan; Dahlbäck, Björn (2006). "Gas6 and protein S". FEBS Journal. 273 (23): 5231–5244. doi:10.1111/j.1742-4658.2006.05529.X. PMID 17064312. S2CID 13383158.
- Dahlbäck, Björn (2008). "Advances in understanding pathogenic mechanisms of thrombophilic disorders". Blood. 112 (1): 19–27. doi:10.1182/blood-2008-01-077909. PMID 18574041.
- Dahlbäck, Björn (2000). "Blood coagulation". The Lancet. 355 (9215): 1627–1632. doi:10.1016/S0140-6736(00)02225-X. PMID 10821379. S2CID 31246121.
- Christoffersen, C.; Obinata, H.; Kumaraswamy, S. B.; Galvani, S.; Ahnstrom, J.; Sevvana, M.; Egerer-Sieber, C.; Muller, Y. A.; Hla, T.; Nielsen, L. B.; Dahlback, B. (2011). "Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M". Proceedings of the National Academy of Sciences. 108 (23): 9613–9618. Bibcode:2011PNAS..108.9613C. doi:10.1073/pnas.1103187108. PMC 3111292. PMID 21606363.
References
[edit]- ^ a b "Björn Dahlbäck, Senior Professor". Lund University.
- ^ a b c d e "Björn Dahlbäck, Biography". eMedEvents.
- ^ Dahlbäck, Björn (1981). The activation of prothrombin on the platelet surface. Malmö.
{{cite book}}: CS1 maint: location missing publisher (link) - ^ a b "Professeur Björn Dahlbäck, Laureate de Prix Louis-Jeantet de médecine 1996". Fondation Louis-Jeantet. October 2017. (in French)
- ^ Vincent, Lisa M.; Tran, Sinh; Livaja, Ruzica; Bensend, Tracy A.; Milewicz, Dianna M.; Dahlbäck, Björn (2013). "Coagulation factor VA2440G causes east Texas bleeding disorder via TFPIα". Journal of Clinical Investigation. 123 (9): 3777–3787. doi:10.1172/JCI69091. PMC 3754264. PMID 23979162.
- ^ "H.M. Konungens Medalj". Sveriges Kungahaus. June 6, 2019. Archived from the original on February 7, 2020. Retrieved October 6, 2022.
- ^ "Björn Dahlbäck". Kungliga Vetenskaps Akademien.
- ^ Lichtman, Marshall A.; Boxer, Laurence A.; Spivak, Jerry L.; Henderson, Edward; Shattil, Sanford J., eds. (27 April 2000). Hematology: Landmark Papers of the Twentieth Century. Academic Press. ISBN 9780124485105.
- ^ Svensson, Peter J.; Dahlback, Bjorn (1994). "Resistance to Activated Protein C as a Basis for Venous Thrombosis". New England Journal of Medicine. 330 (8): 517–522. doi:10.1056/NEJM199402243300801. PMID 8302317.
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