Boswellia serrata
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| in Kinnerasani Wildlife Sanctuary, Andhra Pradesh, India. | |
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| Species: | B. serrata
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| Boswellia serrata | |
Boswellia serrata is a plant that produces Indian frankincense, Salai, referred to in Sanskrit as shallaki and in Latin as Olibanum Indicum.[1] the plant is native to much of India and the Punjab region that extends into Pakistan.[2]
Medical usage
In Ayurvedic medicine Indian frankincense has been used for hundreds of years for the treatment of arthritis.[3][4]
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Extracts of Boswellia serrata have been clinically studied for osteoarthritis and joint function, particularly for osteoarthritis of the knee, with the research showing a slight improvement of both pain and function compared to a placebo.[5] Positive effects of Boswellia in some chronic inflammatory diseases including rheumatoid arthritis, bronchial asthma, osteoarthritis, ulcerative colitis and Crohn's disease have been reported.[6] A Boswellia extract marketed under the name Wokvel has undergone human efficacy, comparative, pharmacokinetic studies.[7][8][9] Some see Boswellia serrata as a promising alternative to NSAIDs, warranting further investigation in pharmacological studies and clinical trials.[10][11]
Topical application
Boswellia serrata has been recently developed for topical use in a patent-pending formula in Sano Relief Gel. Boswellia serrata is used in the manufacture of the anti-wrinkle agent "Boswelox",[12] which has been criticised as being ineffective.[13]
Active constituents
Boswellic acid and other pentacyclic triterpene acids are present. Beta-boswellic acid is the major constituent.
Mechanism of action
Animal studies performed in India show ingestion of a defatted alcoholic extract of Boswellia decreased polymorphonuclear leukocyte infiltration and migration, decreased primary antibody synthesis and almost totally inhibited the classical complement pathway.[14][15]
Properties
Shallaki has potent analgesic and anti-inflammatory effects that can reduce the pain and inflammation of joints.[16]
External links
- BBC News Health - Frankincense 'can ease arthritis' Friday 01/08/08
- "Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data". Clin Pharmacokinet. 50: 349–69. Jun 2011. doi:10.2165/11586800-000000000-00000. PMID 21553931. [17]
References
- ^ European Scientific Cooperative on Phytotherapy (2009). E/S/C/O/P Monographs: The Scientific Foundation for Herbal Medicinal Products. Second Edition, Supplement 2009. European Scientific Cooperative on Phytotherapy. p. 184. ISBN 9781901964080.
- ^ "USDA GRIN Taxonomy". Retrieved 15 October 2014.
- ^ "JOINT RELIEF". www.herbcompanion.com. Retrieved 2009-01-12.
- ^ https://americanindianimports.com/content/9_shallaki-natural-anti-inflammatory
- ^ Cameron, M; Chrubasik, S (May 22, 2014). "Oral herbal therapies for treating osteoarthritis". Cochrane Summaries. Retrieved June 6, 2014.
- ^ Ammon, HP (2010). "Modulation of the immune system by Boswellia serrata extracts and boswellic acids". Phytomedicine. 17 (11): 862–7. doi:10.1016/j.phymed.2010.03.003.
- ^ Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in osteoarthritis of knee" Indian Journal of Pharmacology 2007; 39(1) 27-29
- ^ "Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial". Phytomedicine. 10 (1): 3–7. Jan 2003. doi:10.1078/094471103321648593.
- ^ "Pharmacokinetic study of 11-Keto beta-Boswellic acid". Phytomedicine. 11 (2–3): 255–60. Feb 2004. doi:10.1078/0944-7113-00290.
- ^ Abdel-Tawab, M; Werz, O; Schubert-Zsilavecz, M (Jun 2011). "Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data". Clin Pharmacokinet. 50 (6): 349–69. doi:10.2165/11586800-000000000-00000. PMID 21553931.
- ^ Siddiqui, MZ (2011). "Boswellia serrata, a potential antiinflammatory agent: an overview". Indian J Pharm Sci. 73: 255–61. doi:10.4103/0250-474X.93507. PMC 3309643. PMID 22457547.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Wrinkle breakthrough claim from L'Oreal
- ^ L'Oreal slammed over cream claims
- ^ Sharma, ML; Khajuria, A; Kaul, A; et al. (1988). "Effects of salai guggal ex-Boswellia serrata on cellular and humoral immune responses and leukocyte migration". Agents Actions. 24: 161–164. doi:10.1007/bf01968095.
{{cite journal}}: Explicit use of et al. in:|last4=(help) - ^ Sharma, ML; Bani, S; Singh, GB (1989). "Anti-arthriticactivity of boswellic acids in bovine serum albumin (BSA)-induced arthritis". Int J Immunopharmacol. 11: 647–652. doi:10.1016/0192-0561(89)90150-1.
- ^ (Planta Med. 1971 Apr; 19(4): 333-41 for analgesic and psychopharmacological effects of gum resin of Boswalia Serrata by Memon MK)
- ^ Abdel-Tawab, M; Werz, O; Schubert-Zsilavecz, M (Jun 2011). "Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data". Clin Pharmacokinet. 50 (6): 349–69. doi:10.2165/11586800-000000000-00000. PMID 21553931.