C1QTNF5

C1QTNF5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4F3J, 4NN0
Identifiers
Aliases	C1QTNF5, CTRP5, C1q and tumor necrosis factor related protein 5, C1q and TNF related 5, MFRP
External IDs	OMIM: 608752; MGI: 2385958; HomoloGene: 9227; GeneCards: C1QTNF5; OMA:C1QTNF5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	119,340,940 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,020,484 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gallbladder; ; ascending aorta; ; subcutaneous adipose tissue; ; right coronary artery; ; gastric mucosa; ; tibial arteries; ; right lung; ; left coronary artery; ; myometrium;
	Top expressed in
	vasculature of organ; ; olfactory bulb; ; quadriceps femoris muscle; ; choroid plexus; ; striatum of neuraxis; ; adrenal gland; ; choroid plexus of lateral ventricle; ; urinary bladder; ; cerebellum; ; hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	identical protein binding;
Cellular component	extracellular region; collagen; cell projection; membrane; lateral plasma membrane; apical plasma membrane; plasma membrane; transport vesicle; bicellular tight junction; extracellular space;
Biological process	protein secretion; protein trimerization; inner ear development;
	Sources:Amigo / QuickGO
Orthologs
	114902
	235312
	ENSG00000223953
	ENSMUSG00000079592
	Q9BXJ0
	Q8K480; Q8K479
	NM_015645; NM_001278431
	NM_001040631; NM_001040632; NM_001190313; NM_001190319; NM_145613
	NP_001265360; NP_056460
NP_001177243; NP_667337; NP_001035721; NP_001035722; NP_001177242;
	NP_001177248; NP_663588
	Wikidata
View/Edit Human	View/Edit Mouse

C1q and tumor necrosis factor related protein 5, also known as C1QTNF5, is a protein which in humans is encoded by the C1QTNF5 gene.^[5]^[6]

Function

The CTRP5 protein is a member of the C1q / tumor necrosis factor superfamily, which shows diverse functions including cell adhesion and as components of the basement membrane.^[7] C1QTNF5 is mutant in late-onset retinal degeneration.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000223953 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079592 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: C1QTNF5 C1q and tumor necrosis factor related protein 5".
^ Hayward C, Shu X, Cideciyan AV, Lennon A, Barran P, Zareparsi S, Sawyer L, Hendry G, Dhillon B, Milam AH, Luthert PJ, Swaroop A, Hastie ND, Jacobson SG, Wright AF (October 2003). "Mutation in a short-chain collagen gene, CTRP5, results in extracellular deposit formation in late-onset retinal degeneration: a genetic model for age-related macular degeneration". Hum. Mol. Genet. 12 (20): 2657–67. doi:10.1093/hmg/ddg289. PMID 12944416.
^ Shapiro L, Scherer PE (March 1998). "The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor". Curr. Biol. 8 (6): 335–8. doi:10.1016/S0960-9822(98)70133-2. PMID 9512423.

Function

References

Further reading