MIS18A

MIS18A
Identifiers
Aliases	MIS18A, B28, C21orf45, C21orf46, FASP1, MIS18alpha, hMis18alpha, MIS18 kinetochore protein A
External IDs	OMIM: 618137; MGI: 1913828; HomoloGene: 41294; GeneCards: MIS18A; OMA:MIS18A - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	32,279,049 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	90,524,292 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; gonad; ; ventricular zone; ; ganglionic eminence; ; testicle; ; right testis; ; left testis; ; buccal mucosa cell; ; mucosa of sigmoid colon;
	Top expressed in
	Paneth cell; ; primitive streak; ; endocardial cushion; ; endothelial cell of lymphatic vessel; ; primary oocyte; ; abdominal wall; ; hair follicle; ; condyle; ; cumulus cell; ; atrioventricular junction;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding;
Cellular component	chromosome; nucleoplasm; chromosome, centromeric region; nucleus; chromatin; cytosol;
Biological process	cell division; regulation of DNA methylation; cell cycle; chromosome segregation; CENP-A containing chromatin assembly;
	Sources:Amigo / QuickGO
Orthologs
	54069
	66578
	ENSG00000159055
	ENSMUSG00000022978
	Q9NYP9
	Q9CZJ6
	NM_018944
	NM_025642
	NP_061817
	NP_079918
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Mis18-alpha is a protein that in humans is encoded by the MIS18A gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159055 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022978 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M (Jan 2007). "Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1". Developmental Cell. 12 (1): 17–30. doi:10.1016/j.devcel.2006.11.002. PMID 17199038.
^ "Entrez Gene: C21orf45 chromosome 21 open reading frame 45".

External links

Human MIS18A genome location and MIS18A gene details page in the UCSC Genome Browser.

Slavov D, Hattori M, Sakaki Y, Rosenthal A, Shimizu N, Minoshima S, Kudoh J, Yaspo ML, Ramser J, Reinhardt R, Reimer C, Clancy K, Rynditch A, Gardiner K (Apr 2000). "Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21". Gene. 247 (1–2): 215–32. doi:10.1016/S0378-1119(00)00089-5. PMID 10773462.
Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (May 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (Oct 2000). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". The Biochemical Journal. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
Gardiner K, Slavov D, Bechtel L, Davisson M (Jun 2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics. 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID 12036298.
Ye XX, Lu H, Yu Y, Ding N, Zhang NL, Huo KK, Wan DF, Li YY, Gu JR (Mar 2005). "P5644 interacts with phosphatidylinositol-4-phosphate adaptor protein-1 associated protein-1". Molecular and Cellular Biochemistry. 271 (1–2): 151–8. doi:10.1007/s11010-005-5907-6. PMID 15881666. S2CID 2101296.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159055 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022978 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17199038-5] Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M (Jan 2007). "Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1". Developmental Cell. 12 (1): 17–30. doi:10.1016/j.devcel.2006.11.002. PMID 17199038.

[entrez-6] "Entrez Gene: C21orf45 chromosome 21 open reading frame 45".

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References

External links

Further reading