C2orf3

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GCFC2
Identifiers
Aliases GCFC2, C2orf3, DNABF, GCF, TCF9, GC-rich sequence DNA-binding factor 2
External IDs MGI: 2141656 HomoloGene: 2411 GeneCards: GCFC2
RNA expression pattern
PBB GE C2orf3 216305 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001201334
NM_001201335
NM_003203

NM_177884

RefSeq (protein)

NP_001188263
NP_001188264
NP_003194

NP_808552.2
NP_808552

Location (UCSC) Chr 2: 75.65 – 75.71 Mb Chr 6: 81.92 – 81.96 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

GC-rich sequence DNA-binding factor is a protein that in humans is encoded by the C2orf3 gene.[3][4][5][6]

The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Johnson AC, Kageyama R, Popescu NC, Pastan I (Feb 1992). "Expression and chromosomal localization of the gene for the human transcriptional repressor GCF". J Biol Chem. 267 (3): 1689–94. PMID 1370479. 
  4. ^ Kageyama R, Pastan I (Jan 1990). "Molecular cloning and characterization of a human DNA binding factor that represses transcription". Cell. 59 (5): 815–25. doi:10.1016/0092-8674(89)90605-3. PMID 2556218. 
  5. ^ Anthoni H, Zucchelli M, Matsson H, Muller-Myhsok B, Fransson I, Schumacher J, Massinen S, Onkamo P, Warnke A, Griesemann H, Hoffmann P, Nopola-Hemmi J, Lyytinen H, Schulte-Korne G, Kere J, Nothen MM, Peyrard-Janvid M (Apr 2007). "A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia". Hum Mol Genet. 16 (6): 667–77. doi:10.1093/hmg/ddm009. PMID 17309879. 
  6. ^ a b "Entrez Gene: C2orf3 chromosome 2 open reading frame 3". 

External links[edit]

Further reading[edit]