TCIM

TCIM
Identifiers
Aliases	TCIM, TC-1, TC1, C8orf4, chromosome 8 open reading frame 4, transcriptional and immune response regulator
External IDs	OMIM: 607702; MGI: 1916318; HomoloGene: 10590; GeneCards: TCIM; OMA:TCIM - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	40,155,310 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	24,929,000 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; gallbladder; ; right lung; ; vena cava; ; mucosa of urinary bladder; ; seminal vesicula; ; upper lobe of left lung; ; pericardium; ; visceral pleura; ; rectum;
	Top expressed in
	parotid gland; ; lacrimal gland; ; left lung lobe; ; interventricular septum; ; seminal vesicula; ; molar; ; olfactory epithelium; ; epithelium of small intestine; ; intestinal villus; ; brown adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; Notch binding;
Cellular component	cytoplasm; nuclear speck; nucleolus; nucleus; nucleoplasm; cytosol; plasma membrane; intracellular anatomical structure;
Biological process	regulation of cell cycle G1/S phase transition; endothelial cell activation involved in immune response; cellular response to heat; regulation of DNA-templated transcription in response to stress; regulation of hemopoiesis; negative regulation of Notch signaling pathway; apoptotic process; positive regulation of protein kinase A signaling; negative regulation of apoptotic process; positive regulation of protein kinase C activity; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	56892
	69068
	ENSG00000176907
	ENSMUSG00000056313
	Q9NR00
	Q9D915
	NM_020130
	NM_026931
	NP_064515
	NP_081207
	Wikidata
View/Edit Human	View/Edit Mouse

Uncharacterized protein C8orf4 is a protein that in humans is encoded by the C8orf4 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176907 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056313 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chua EL, Young L, Wu WM, Turtle JR, Dong Q (Nov 2000). "Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer". Genomics. 69 (3): 342–7. doi:10.1006/geno.2000.6348. PMID 11056052.
^ "Entrez Gene: C8orf4 chromosome 8 open reading frame 4".

References

Further reading