This is an old revision of this page, as edited by Jmertel23(talk | contribs) at 20:07, 8 February 2018(added wikilinks and removed "underlinked" tag). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.
Revision as of 20:07, 8 February 2018 by Jmertel23(talk | contribs)(added wikilinks and removed "underlinked" tag)
Calpain 6 is a protein in humans that is encoded by the CAPN6 gene.
[5]
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009].