CHD5

CHD5
Identifiers
Aliases	CHD5, CHD-5, chromodomain helicase DNA binding protein 5, PMNDS
External IDs	OMIM: 610771; MGI: 3036258; HomoloGene: 56712; GeneCards: CHD5; OMA:CHD5 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	6,180,321 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	152,474,651 bp
RNA expression pattern
	Top expressed in
	sperm; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 10; ; Brodmann area 9; ; pituitary gland; ; left testis; ; right testis; ; primary visual cortex;
	Top expressed in
	subiculum; ; central gray substance of midbrain; ; dorsal tegmental nucleus; ; cingulate gyrus; ; visual cortex; ; habenula; ; lateral hypothalamus; ; primary visual cortex; ; medial vestibular nucleus; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; helicase activity; metal ion binding; H3K27me3 modified histone binding; hydrolase activity; ATP binding;
Cellular component	NuRD complex; membrane; heterochromatin; nucleus; nucleoplasm; cytosol; nuclear speck;
Biological process	cell differentiation; regulation of transcription, DNA-templated; histone H3-K27 trimethylation; positive regulation of signal transduction by p53 class mediator; transcription, DNA-templated; nervous system development; spermatogenesis; histone H4 acetylation; cerebral cortex neuron differentiation; negative regulation of cell population proliferation; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	26038
	269610
	ENSG00000116254
	ENSMUSG00000005045
	Q8TDI0
	A2A8L1
	NM_015557
	NM_001081376; NM_029216; NM_001369243
	NP_056372
	NP_001074845; NP_083492; NP_001356172
	Wikidata
View/Edit Human	View/Edit Mouse

Chromodomain-helicase-DNA-binding protein 5 is an enzyme that in humans is encoded by the CHD5 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116254 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005045 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schuster EF, Stoger R (Mar 2002). "CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases". Mamm Genome. 13 (2): 117–9. doi:10.1007/s00335-001-3042-6. PMID 11889561.
^ Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM (Feb 2003). "CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system". Oncogene. 22 (7): 1002–11. doi:10.1038/sj.onc.1206211. PMID 12592387.
^ "Entrez Gene: CHD5 chromodomain helicase DNA binding protein 5".

References

Further reading