Calcineurin B homologous protein 1

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  (Redirected from CHP (gene))
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Protein CHP PDB 2ct9.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesCHP1, CHP, SLC9A1BP, Sid470p, p22, p24, calcineurin like EF-hand protein 1
External IDsMGI: 1927185 HomoloGene: 5235 GeneCards: CHP1
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for CHP1
Genomic location for CHP1
Band15q15.1Start41,230,839 bp[1]
End41,281,887 bp[1]
RNA expression pattern
PBB GE CHP 214665 s at fs.png

PBB GE CHP 207993 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 15: 41.23 – 41.28 MbChr 2: 119.55 – 119.59 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Calcineurin B homologous protein 1 is protein encoded in humans by the CHP1 gene (formerly CHP).[5]


The protein encoded by this gene is a phosphoprotein that binds to the sodium-hydrogen exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity.[5]


Calcineurin B homologous protein 1 has been shown to interact with


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187446 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014077 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: CHP calcium binding protein P22".
  6. ^ a b Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H (Feb 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biological & Pharmaceutical Bulletin. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672.
  7. ^ Lin X, Barber DL (Oct 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
  8. ^ Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". The Journal of Biological Chemistry. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
  9. ^ Zhang-James Y, DasBanerjee T, Sagvolden T, Middleton FA, Faraone SV (Dec 2011). "SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder". American Journal of Medical Genetics Part B. 156B (7): 835–43. doi:10.1002/ajmg.b.31229. PMC 3168688. PMID 21858920.

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