Calcineurin B homologous protein 1

From Wikipedia, the free encyclopedia
  (Redirected from CHP (gene))
Jump to: navigation, search
Protein CHP PDB 2ct9.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases CHP1, CHP, SLC9A1BP, Sid470p, p22, p24, calcineurin like EF-hand protein 1
External IDs MGI: 1927185 HomoloGene: 5235 GeneCards: CHP1
RNA expression pattern
PBB GE CHP 214665 s at fs.png

PBB GE CHP 207993 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 15: 41.23 – 41.28 Mb Chr 2: 119.55 – 119.59 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Calcineurin B homologous protein 1 is protein encoded in humans by the CHP1 gene (formerly CHP).[3]


The protein encoded by this gene is a phosphoprotein that binds to the sodium-hydrogen exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity.[3]


Calcineurin B homologous protein 1 has been shown to interact with


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: CHP calcium binding protein P22". 
  4. ^ a b Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H (Feb 2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biological & Pharmaceutical Bulletin. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672. 
  5. ^ Lin X, Barber DL (Oct 1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044Freely accessible. PMID 8901634. 
  6. ^ Pang T, Su X, Wakabayashi S, Shigekawa M (May 2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". The Journal of Biological Chemistry. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981. 
  7. ^ Zhang-James Y, DasBanerjee T, Sagvolden T, Middleton FA, Faraone SV (Dec 2011). "SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder". American Journal of Medical Genetics Part B. 156B (7): 835–43. doi:10.1002/ajmg.b.31229. PMC 3168688Freely accessible. PMID 21858920. 

External links[edit]

Further reading[edit]