CITED1

CITED1
Identifiers
Aliases	CITED1, MSG1, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
External IDs	OMIM: 300149; MGI: 108023; HomoloGene: 3057; GeneCards: CITED1; OMA:CITED1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	72,307,187 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	101,295,787 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; anterior pituitary; ; hypothalamus; ; testicle; ; prefrontal cortex; ; anterior cingulate cortex; ; amygdala; ; dorsolateral prefrontal cortex; ; superior frontal gyrus;
	Top expressed in
	yolk sac; ; morula; ; tail of embryo; ; reticular formation; ; atrium; ; paraxial mesoderm; ; lactiferous gland; ; raphe nuclei; ; endocardium; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; co-SMAD binding; protein homodimerization activity; DNA-binding transcription factor activity; chromatin binding; LBD domain binding; protein C-terminus binding; protein binding;
Cellular component	cytoplasm; cytosol; nucleus; nucleoplasm;
Biological process	negative regulation of neuron apoptotic process; response to transforming growth factor beta; positive regulation of transforming growth factor beta receptor signaling pathway; cell differentiation; response to cytokine; melanin biosynthetic process; spongiotrophoblast layer development; response to interleukin-1; regulation of transcription, DNA-templated; SMAD protein signal transduction; response to interleukin-4; response to interferon-gamma; response to interleukin-6; placenta development; regulation of transcription by RNA polymerase II; response to interleukin-2; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; labyrinthine layer development; response to interleukin-11; negative regulation of Wnt signaling pathway; embryonic axis specification; negative regulation of osteoblast differentiation; transcription, DNA-templated; response to estrogen; vasculogenesis; positive regulation of transcription, DNA-templated; response to insulin; multicellular organism development; response to lipopolysaccharide; branching involved in ureteric bud morphogenesis; brain development; positive regulation of gene expression; response to parathyroid hormone; nucleocytoplasmic transport; pigmentation; response to cAMP; cell population proliferation; metanephros development; melanocyte differentiation; negative regulation of transcription, DNA-templated; response to interleukin-9; transforming growth factor beta receptor signaling pathway; mesenchymal to epithelial transition; apoptotic process; positive regulation of transcription by RNA polymerase II; regulation of apoptotic process; transcription by RNA polymerase II; positive regulation of mesenchymal stem cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	4435
	12705
	ENSG00000125931
	ENSMUSG00000051159
	Q99966
	P97769
	NM_001144885; NM_001144886; NM_001144887; NM_004143
	NM_001276466; NM_001276473; NM_001276474; NM_007709
	NP_001138357; NP_001138358; NP_001138359; NP_004134
	NP_001263395; NP_001263402; NP_001263403; NP_031735
	Wikidata
View/Edit Human	View/Edit Mouse

Cbp/p300-interacting transactivator 1 is a protein that in humans is encoded by the CITED1 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

CITED1 has been shown to interact with HSPA8^[8] and EP300.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125931 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051159 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shioda T, Fenner MH, Isselbacher KJ (December 1996). "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation". Proc Natl Acad Sci U S A. 93 (22): 12298–303. doi:10.1073/pnas.93.22.12298. PMC 37985. PMID 8901575.
^ Fenner MH, Parrish JE, Boyd Y, Reed V, MacDonald M, Nelson DL, Isselbacher KJ, Shioda T (October 1998). "MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis". Genomics. 51 (3): 401–7. doi:10.1006/geno.1998.5383. PMID 9721210.
^ "Entrez Gene: CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1".
^ ^a ^b Yahata, T; de Caestecker M P; Lechleider R J; Andriole S; Roberts A B; Isselbacher K J; Shioda T (March 2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors". J. Biol. Chem. 275 (12). UNITED STATES: 8825–34. doi:10.1074/jbc.275.12.8825. ISSN 0021-9258. PMID 10722728. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading