COPS8

COPS8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D10, 4D18, 4WSN
Identifiers
Aliases	COPS8, COP9, CSN8, SGN8, COP9 signalosome subunit 8
External IDs	OMIM: 616011; MGI: 1915363; HomoloGene: 4882; GeneCards: COPS8; OMA:COPS8 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	237,100,474 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	90,541,063 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; endothelial cell; ; lateral nuclear group of thalamus; ; Brodmann area 23; ; middle temporal gyrus; ; pars reticulata; ; Pars compacta; ; pons; ; Skeletal muscle tissue of biceps brachii; ; external globus pallidus;
	Top expressed in
	spermatocyte; ; yolk sac; ; facial motor nucleus; ; ventricular zone; ; muscle of thigh; ; primary oocyte; ; primitive streak; ; neural tube; ; secondary oocyte; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	perinuclear region of cytoplasm; extracellular exosome; nucleus; nucleoplasm; cytoplasm; cytosol; COP9 signalosome;
Biological process	transcription-coupled nucleotide-excision repair; activation of NF-kappaB-inducing kinase activity; nucleotide-excision repair, DNA damage recognition; negative regulation of cell population proliferation; COP9 signalosome assembly; protein deneddylation; post-translational protein modification; protein phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	10920
	108679
	ENSG00000198612
	ENSMUSG00000034432
	Q99627
	Q8VBV7
	NM_198189; NM_006710
	NM_133805
	NP_006701; NP_937832
	NP_598566
	Wikidata
View/Edit Human	View/Edit Mouse

COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198612 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034432 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chamovitz DA, Deng XW (Sep 1995). "The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms". Cell. 82 (3): 353–4. doi:10.1016/0092-8674(95)90423-9. PMID 7634324.
^ Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R, Kisselev AF, Tanaka K, Nakatani Y (May 2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell. 113 (3): 357–67. doi:10.1016/S0092-8674(03)00316-7. PMID 12732143.
^ "Entrez Gene: COPS8 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)".

References

Further reading