CPLX2

CPLX2
Identifiers
Aliases	CPLX2, 921-L, CPX-2, CPX2, Hfb1, complexin 2
External IDs	OMIM: 605033; MGI: 104726; HomoloGene: 38212; GeneCards: CPLX2; OMA:CPLX2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	175,884,021 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	54,531,730 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; amygdala; ; caudate nucleus; ; anterior cingulate cortex; ; dorsolateral prefrontal cortex; ; prefrontal cortex; ; nucleus accumbens; ; hippocampus proper; ; postcentral gyrus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; olfactory tubercle; ; cerebellar cortex; ; nucleus accumbens; ; globus pallidus; ; subiculum; ; cerebellar vermis; ; lobe of cerebellum; ; piriform cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	syntaxin-1 binding; syntaxin binding; SNARE binding; calcium-dependent protein binding;
Cellular component	cytoplasm; cytosol; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex; mast cell granule; synapse; synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex; soma; dendrite; SNARE complex; presynapse; calyx of Held; postsynapse; glutamatergic synapse; terminal bouton;
Biological process	cell differentiation; synaptic vesicle exocytosis; nervous system development; positive regulation of synaptic plasticity; vesicle docking involved in exocytosis; regulation of exocytosis; mast cell degranulation; neurotransmitter transport; exocytosis; regulation of synaptic vesicle fusion to presynaptic active zone membrane; regulation of neurotransmitter secretion;
	Sources:Amigo / QuickGO
Orthologs
	10814
	12890
	ENSG00000145920
	ENSMUSG00000025867
	Q6PUV4
	P84086
	NM_001008220; NM_006650; NM_032282
	NM_009946; NM_001362218
	NP_001008221; NP_006641
	NP_034076; NP_001349147
	Wikidata
View/Edit Human	View/Edit Mouse

Complexin-2 is a protein that in humans is encoded by the CPLX2 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145920 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025867 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McMahon HT, Missler M, Li C, Sudhof TC (Nov 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862.
^ Raevskaya NM, Dergunova LV, Vladychenskaya IP, Stavchansky VV, Oborina MV, Poltaraus AB, Limborska SA (Sep 2005). "Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity". Gene. 359: 127–37. doi:10.1016/j.gene.2005.07.005. PMID 16162394.
^ "Entrez Gene: CPLX2 complexin 2".

External links

Human CPLX2 genome location and CPLX2 gene details page in the UCSC Genome Browser.

References

External links

Further reading