CSRP2

CSRP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CU8
Identifiers
Aliases	CSRP2, CRP2, LMO5, SmLIM, cysteine and glycine rich protein 2
External IDs	OMIM: 601871; MGI: 1202907; HomoloGene: 111061; GeneCards: CSRP2; OMA:CSRP2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	76,879,023 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	110,775,483 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; ganglionic eminence; ; tibial arteries; ; right coronary artery; ; mucosa of paranasal sinus; ; parietal pleura; ; gingival epithelium; ; gastric mucosa; ; optic nerve;
	Top expressed in
	ascending aorta; ; aortic valve; ; tunica media of zone of aorta; ; umbilical cord; ; endocardial cushion; ; atrium; ; mandibular prominence; ; external carotid artery; ; atrioventricular valve; ; internal carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; molecular function; structural constituent of muscle; actinin binding;
Cellular component	nucleus; focal adhesion; cytoplasm; Z discdkac;
Biological process	multicellular organism development; cell differentiation; actin cytoskeleton organization; sarcomere organization; muscle tissue development;
	Sources:Amigo / QuickGO
Orthologs
	1466
	13008
	ENSG00000175183
	ENSMUSG00000020186
	Q16527
	P97314
	NM_001300965; NM_001321
	NM_007792
	NP_001287894; NP_001312
	NP_031818
	Wikidata
View/Edit Human	View/Edit Mouse

Cysteine and glycine-rich protein 2 is a protein that in humans is encoded by the CSRP2 gene.^[5]^[6]^[7]

CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175183 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020186 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (Jan 1996). "The cysteine-rich protein family of highly related LIM domain proteins". J Biol Chem. 270 (48): 28946–54. doi:10.1074/jbc.270.48.28946. PMID 7499425.
^ Weiskirchen R, Erdel M, Utermann G, Bister K (Nov 1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2". Genomics. 44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID 9286703.
^ ^a ^b "Entrez Gene: CSRP2 cysteine and glycine-rich protein 2".

External links

Human CSRP2 genome location and CSRP2 gene details page in the UCSC Genome Browser.

Jain MK, Fujita KP, Hsieh CM, Endege WO, Sibinga NE, Yet SF, Kashiki S, Lee WS, Perrella MA (1996). "Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells". J. Biol. Chem. 271 (17): 10194–9. doi:10.1074/jbc.271.17.10194. PMID 8626582.
Karim MA, Ohta K, Egashira M, Jinno Y, Niikawa N, Matsuda I, Indo Y (1997). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics. 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID 8824798.
Weiskirchen R, Gressner AM (2000). "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP)". Biochem. Biophys. Res. Commun. 274 (3): 655–63. doi:10.1006/bbrc.2000.3187. PMID 10924333.
Weiskirchen R, Moser M, Weiskirchen S, Erdel M, Dahmen S, Buettner R, Gressner AM (2001). "LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1". Biochem. J. 359 (Pt 3): 485–96. doi:10.1042/0264-6021:3590485. PMC 1222169. PMID 11672422.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wang M, Hu Y, Shima I, Stearns ME (2003). "IL-10/IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate tumor lines". Cancer Biol. Ther. 1 (5): 556–63. doi:10.4161/cbt.1.5.222. PMID 12496489.
Stearns ME, Wang M, Hu Y, Garcia FU (2004). "Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines". Mol. Cancer Res. 1 (9): 631–42. PMID 12861049.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175183 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020186 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7499425-5] Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (Jan 1996). "The cysteine-rich protein family of highly related LIM domain proteins". J Biol Chem. 270 (48): 28946–54. doi:10.1074/jbc.270.48.28946. PMID 7499425.

[pmid9286703-6] Weiskirchen R, Erdel M, Utermann G, Bister K (Nov 1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2". Genomics. 44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID 9286703.

[entrez-7] "Entrez Gene: CSRP2 cysteine and glycine-rich protein 2".

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References

External links

Further reading