Café Pamplona, located at 12 Bow St. beside the intersection of Bow and Arrow Streets near Harvard Square, Cambridge, Massachusetts, USA, is a café. When it opened in 1959 it was the first café in the Square. The owner, Josefina Yanguas, claimed the café had the first espresso-maker in the city. Down a short flight of exterior stairs, past a patio with tables, customers enter the café's subterranean interior. The once austere decor includes bright yellow lights which make the thickly-plastered walls glow under low ceilings, and a black and white checked floor. The café survived the changes that have taken place since the mid-1980s.
Shortly after the café opened Yanguas and her Cuban chef Juana Rodríguez began preparing and serving food. As business grew Yanguas began to hire only men, in accord with the usual Spanish practice of having a single-sex staff, until 1999. In the Fall of that year this policy was revealed by the Harvard Crimson. Manager James Timberlake hired Jenny Follen in late 1999, the first female employee in the cafe's 40 year; since then time the café has observed standard hiring practices.
The café attracts both bohemians and academics from both nearby Harvard University and the greater Cambridge community. Notable patrons of the café include Al Gore, and Amanda Palmer. 
The small mural on a wall in the cafe was painted fresco-style directly on site, by local artist Conger Metcalf, a friend of the owner. Completed some time in the late Sixties, its yellowed background is due to years of exposure to cigarette smoke. During this period the walls in the café needed to be repainted every four years as they would significantly yellow from smoke. While the central figure looks strikingly like Yanguas, she said it was not her portrait.
In December 2004, after 46 years, Yanguas put the Pamplona up for sale, but did not generate significant interest. In May 2005, she reopened the Café. She died on August 1, 2007 at the age of 90, though the café continues in operation (as of December 2016[update]).
Throughout the years the café and Josefina's house have been mentioned by a variety of media outlets. It has won best café in the Boston area in Improper Bostonian, and other local publications. In 2000 an architectural exposé was written about Josefina's apartment in the Boston Globe Magazine. The café has been mentioned on NPR and in variety of artists' reflections. Because of its atmosphere and history, Pamplona served as the inspiration for a variety of artists and thinkers. Reminiscent anecdotes of reading, working and talking in the café are recounted by a number of Harvard and Cambridge luminaries.
- The location for one of the scenes in the film version of Prozac Nation.
- Accounts of the café regularly appear in memoirs, including Pepper White's The Idea Factory: Learning to Think at MIT.
- In April 2004 painter and sculptor (and former head waiter 1999-2005), Jeffrey P. Smith, built an art installation for the Boston Museum School 5th Year program. Called "Space for Solitude", it was largely based on architectural details of the café. The door which had been on the café since its opening (1959–2004) was the same door used in Smith's installation. In his catalogue essay he dedicated the work in part to owner Josefina Yanguas.
- In January and February 2006, the café's courtyard was the site of a temporary public art installation by DeWitt Godfrey titled "Pamplona," and sponsored by the Cambridge Arts Council.
- Café Pamplona is mentioned in The Dresden Dolls' song "Truce", composed by Amanda Palmer:
"You can have Africa, Asia, Australia, as long as you keep your hands off Café Pamplona."
- Café Pamplona is also mentioned in the 2003 Jhumpa Lahiri novel The Namesake
- Café Pamplona appears in the background of the rooftop photo of Claudia Gonson in the booklet in The Magnetic Fields' CD box set of 69 Love Songs
- Café Pamplona is also mentioned in Part III ("The New World") of Eva Hoffman's memoir Lost In Translation: A Life in a New Language.
- Cafe Pamplona & Cambridge Iruna Cookbook, by Josefina Yanguas, Lulu.com, February, 2005, ISBN 1-4116-2356-8 ISBN 978-1411623569
- The Harvard Crimson :: Continental Cafe
- The Harvard Crimson :: News :: Beloved Pamplona Owner Dies at 90
- The Harvard Crimson :: Magazine :: Fifteen Minutes: A Strange Brew at Pamplona: Waiters Wanted, Women Need Not Apply
- The Harvard Crimson :: News :: Cafe Revamps Food, Not Image
- Long Day Into Square August 2010
- The Dresden Dolls Diary: February 2007
- The Dresden Dolls Diary: January 2007
- The Dresden Dolls Diary: December 2006
- The Dresden Dolls Diary: July 2005
- The Dresden Dolls Diary: December 2004
- Conger A. Metcalf (1914 - 1998)
- The Harvard Crimson :: News :: Cafe Pamplona Will Close Doors
- The Harvard Crimson :: News :: Cafe Pamplona Returns to Square
- Josefina Yanguas, 90; her Cambridge café served as a gathering place for intellectuals - The Boston Globe
- Cambridge, USA Office of Tourism: CAFE PAMPLONA
- The Idea Factory - The MIT Press
- Cambridge Arts Council :: About CAC