Cancer cluster

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A cancer cluster is a disease cluster in which a high number of cancer cases occurs in a group of people in a particular geographic area over a limited period of time.[1]

Historical examples of work-related cancer clusters are well documented in the medical literature. Notable examples include: scrotal cancer among chimney sweeps in 18th century London; osteosarcoma among female watch dial painters in the 20th century; skin cancer in farmers; bladder cancer in dye workers exposed to aniline compounds; and leukemia and lymphoma in chemical workers exposed to benzene.[2]

Cancer cluster suspicions usually arise when members of the general public report that their family members, friends, neighbors, or coworkers have been diagnosed with the same or related cancers. State or local health departments will investigate the possibility of a cancer cluster when a claim is filed.[3] In order to justify investigating such claims, health departments conduct a preliminary review. Data will be collected and verified regarding: the types of cancer reported, numbers of cases, geographic area of the cases, and the patients clinical history. At this point, a committee of medical professionals will examine the data and determine whether or not an investigation (often lengthy and expensive) is justified.[4]

In the U.S., state and local health departments respond to more than 1,000 inquiries about suspected cancer clusters each year. It is possible that a suspected cancer cluster may be due to chance alone; however, only clusters that have a disease rate that is statistically significantly greater than the disease rate of the general population are investigated. Given the number of inquiries it is likely that many of these are due to chance alone. It is a well-known problem in interpreting data that random cases of cancer can appear to form clumps that are misinterpreted as a cluster.[5]

A cluster is less likely to be coincidental if the case consists of one type of cancer, a rare type of cancer, or a type of cancer that is not usually found in a certain age group. Between 5% to 15% of suspected cancer clusters are statistically significant.[3]


Statisticians examining data for cancer clusters must beware of random coincidences, which seem to form a pattern.[5] In this randomly generated scatter graph, arcs and patterns appear to exist that have formed only by coincidence.

In 2007 the Associated Press reported a confirmed cancer cluster in Delaware,

Delaware health officials have confirmed what residents near a coal-fired power plant long suspected: there is a cluster of cancer cases near the Indian River Power Plant. The News Journal reported Sunday that the rate of cancer cases in the area is 7 percent higher than the national average...The state study was released last month to Lt. Gov. John Carney, who requested the report.."[6]

The same article noted that "the Division of Public Health is unlikely to study the matter further. The Department cited a lack of resources" as well as the difficulty of "pinning down" a precise environmental cause. The findings were reported elsewhere.[7][8][9]

In 2007, the village of Shangba acquired the nickname China's "Village of Death" due to the extremely high incidence of cancer in its population.[10]

See also[edit]


  1. ^ Cancer Cluster FAQ. Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Environmental Hazards and Health Effects.
  2. ^ Cancer Facts. National Cancer Institute. U.S. National Institutes of Health.
  3. ^ a b Thun, M. J. & Sinks, T. (2004), "Understanding Cancer Clusters", CA Cancer J Clin, 54 (5): 273–280, doi:10.3322/canjclin.54.5.273, PMID 15371285 
  4. ^ Devier, J. R.; Brownson, R. C.; Bagby, J. R., Jr.; Carlson, G. M.; Crellin, J. R. & C (1990), "A public health response to cancer clusters in Missouri", Am J Epidemiol, 132 (1): S23–31, PMID 2356832 
  5. ^ a b Blastland, Michael. "Go Figure: How can you explain cancer clusters?". BBC News Online. Retrieved 7 April 2016. 
  6. ^ Associated, Press (August 6, 2007), "Cancer cluster found near power plant", The Daily Times (Salisbury, MD), p. 1 
  7. ^ Cancer cluster found near Del. power plant
  8. ^ Eight cancer clusters discovered in Delaware
  9. ^ The Big Waste Disposal Problem
  10. ^ "China's 'cancer villages' pay price". BBC News. 17 January 2007. Retrieved 18 March 2014. 

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