Candex is a dietary supplement manufactured by Pure Essence Laboratories. It is marketed as an enzymatic remedy to treat the yeast infection candida. Having the status of a dietary supplement, its efficiency has not been proven in scientifically controlled and peer-reviewed trials. Similar formulas exist, such as Candigest.
Mechanism of action
Candex contains the fibre digesting enzymes, cellulase and hemicellulase. The manufacturer claims because yeast cell walls are built mainly of fibre, which is mostly made of the complex carbohydrate, cellulose, cellulase and hemicellulase are capable of killing yeast.
However, a review of the scientific literature suggests that this mechanism of action is unlikely to be true. For while plant cell walls are made predominantly of cellulose, yeast cell walls are not (yeast are classified as fungi). For example, in the article, "Synthesis of the yeast cell wall and its regulation" in the Annual Review of Biochemistry, there is mention of many other complex carbohydrates found in yeast cell walls, but there is no mention of cellulose nor is cellulose mentioned as a cell wall component in candida albicans, the yeast strain most frequently associated with human fungal infections. Indeed, scientists have even modified yeast cells so they can make their own cellulases. This allows the modified yeast to ferment widely available plant material, which is made mostly of cellulose, and turn plant cellulose into alcohol for biofuels (cellulosic ethanol). One scientific article even called yeast an "ideal host strain" for producing cellulases. This is consistent with cellulase not being toxic to yeast and no mention was made of any toxic effect of cellulases on the modified yeast.
Furthermore, while many internet sites claim that cellulase enzymes might degrade the chitin found in yeast cell walls, once again no evidence is presented for this. Enzymes are known to be highly specific and in general cellulases have not been found to be active on chitin. To quote one scientific article: "The purified cellulase was devoid of chitinase, pectinase and mannanase activities". Moreover, in contrast to the previously mentioned fact that yeast bioengineered to make cellulases remain healthy, when a chitinase gene was bioengineered into the same yeast strain it resulted in complete growth inhibition. This again suggests cellulases do not in general contain significant chitinase activity.
Similarly, although many internet sites claim cellulase degrades yeast biofilms, no peer-reviewed scientific evidence was offered in support of this. The exact chemical composition of yeast biofilms remains poorly understood and although there is evidence for it containing many different types of polysaccharides, there was no evidence presented that it contains cellulose or is susceptible to cellulase digest.
The manufacturer further claims Candex enzymes kill yeast but don't stimulate the yeast to release toxins, thereby avoiding unpleasant die-off reactions, contrary to using fungicidal drugs and herbs. But once again, there is no reference to a peer-reviewed scientific journal to support these claims. An alternative explanation might be that there are no unpleasant die-off reactions simply because the Candex enzymes do not effectively kill yeast.
The remaining enzymes found in Candex: amylase, glucoamylase, diastase, and invertase are involved in basic carbohydrate and sugar metabolic pathways and are not involved in cell wall lysis. For example, Invertase catalyzes the conversion of sucrose (common table sugar) into glucose and fructose. Much of the invertase used in the food industry is actually purified from yeast itself as yeast contain an abundance of their own naturally produced invertase.
Candex is sold in sizes of 40 or 120 capsules. 4 capsules equal one daily dose, which may later be reduced. 4 capsules contain:
|Vegetarian Cellulase||148,000 CU|
|Vegetarian Hemicellulase||60,000 HCU|
|Vegetarian Amylase||8000 DU|
|Vegetarian Glucoamylase||400 mg|
|Vegetarian Invertase||1200 SU|
|Vegetarian Malt Diastase||400 DP|
This section needs additional citations for verification. (December 2008) (Learn how and when to remove this template message)
Trials and tests
A non-verified study from 2002 by the Progressive Medical Group claims that after testing the remedy on 52 patients, all of them had "at least minimal improvement not only in any upper gastrointestinal symptoms (probably associated with the natural digestive enzyme), but also in lower gastrointestinal symptoms and yeast-associated problems (altered cognition, craving carbohydrates, arthralgias, myalgias, allergies, etc.)." The study claims that side effects were "minimal with only rare gastrointestinal symptoms (nausea, etc.) that resolved when association with food intake was altered", and that these side effects were deemed to not be statistically significant. The study has not been reviewed by scientific peers, nor published in medical journals. Some have questioned its usefulness due to the lack of a control group.
- E Cabib; R Roberts & B Bowers (July 1982). "Synthesis of the Yeast Cell Wall and its Regulation". Annual Review of Biochemistry. 51: 763–793. doi:10.1146/annurev.bi.51.070182.003555.
- Masuoka, J (April 2004). "Surface Glycans of Candida albicans and Other Pathogenic Fungi". Clinical Reviews of Microbiology. 17 (2): 281–310. doi:10.1128/cmr.17.2.281-310.2004. PMC 387410. PMID 15084502.
- Yamada R, Hasunuma T, Kondo A (Nov 2013). "Endowing non-cellulolytic microorganisms with cellulolytic activity aiming for consolidated bioprocessing". Biotechnol Adv. 31 (6): 754–63. doi:10.1016/j.biotechadv.2013.02.007. PMID 23473971.
- PL Hurst; PA Sullivan; MG Sheperd (1978). "Substrate Specificity and Mode ofAction of a Celiulase" (PDF). Biochem. J. 169: 390.
- Lim H, Choi HT (Oct 2010). "Growth inhibition of the yeast transformant by the expression of a chitinase from Coprinellus congregatus". J Microbiol. 48 (5): 706–708. doi:10.1007/s12275-010-0272-x. PMID 21046352.
- MA Al-Fattani & LJ Douglas (Aug 2006). "Biofilm matrix of Candida albicans and Candida tropicalis: chemical composition and role in drug resistance". Journal of Medical Microbiology. 55 (8): 999–1008. doi:10.1099/jmm.0.46569-0.
- Nam Sun Wang. "Enzyme Kinetics of Invertase". Retrieved 5 December 2013.
- Pure Essence Candex 120 Cap., SMARTbomb.com
- Candex, A Clinical Study, CoastHerbal.com
- PubMed database, 21 Jan. 2007