Daubeny was born at Stratton near Cirencester in Gloucestershire, the son of the Rev. James Daubeny. He studied at Magdalen College, Oxford, under Dr. John Kidd. From 1815 to 1818 he studied medicine in London and Edinburgh. He took his M.D. degree at Oxford, and was a fellow of the College of Physicians.
In 1819, in the course of a tour through France, he made the volcanic district of Auvergne a special study, and his Letters on the Volcanos of Auvergne were published in The Edinburgh Journal. He was elected a fellow of the Royal Society in 1822.
By subsequent journeys in Hungary, Transylvania, Italy, Sicily, France and Germany he extended his knowledge of volcanic phenomena; and in 1826 the results of his observations were given in a work entitled A Description of Active and Extinct Volcanos. In common with Gay-Lussac and Davy, he held subterraneous thermic disturbances to be probably due to the contact of water with metals of the alkalis and alkaline earths.
In November 1822 Daubeny succeeded Kidd as professor of chemistry at Oxford, and retained this post until 1855. In 1834 he was appointed to the chair of botany, to which was subsequently attached that of rural economy. At the Oxford botanical garden he conducted numerous experiments upon the effect of changes in soil, light and the composition of the atmosphere upon vegetation. In 1830 he published in the Philosophical Transactions a paper on the iodine and bromine of mineral waters. In 1831 Daubeny represented the universities of England at the first meeting of the British Association, which at his request held their next session at Oxford. In 1836 he communicated to the Association a report on the subject of mineral and thermal waters.
In 1837 he visited the United States and acquired there the materials for papers on the thermal springs and the geology of North America, read in 1838 before the Ashmolean Society and the British Association (and published in 1839). In 1856 he became president of the latter body at its meeting at Cheltenham. The herbarium at Oxford is named after him, as is the plant genus Daubenya.
- A Description of active and extinct volcanos (1826)
- Introduction to the Atomic Theory (1831); 2nd edition, 1850
- On the Action of Light upon Plants, and of Plants upon the Atmosphere (1836)
- Sketch of the Geology of North America (1839)
- Lectures on Agriculture (1841)
- Journal of a tour through the United States, and in Canada, made during the years 1837–38 (1843)
- Lectures on Roman Husbandry (1857); in Climate: an inquiry into the causes of its differences and into its influence on Vegetable Life (1863)
- Essay on the Trees and Shrubs of the Ancients, and Catalogue of the Trees and Shrubs indigenous to Greece and Italy (1865)
- Miscellanies: being a collection of memoirs and essays on scientific and literary subjects published at various times (1867)
- "Daubeny, Charles Giles Bridle". Dictionary of National Biography. London: Smith, Elder & Co. 1885–1900.
- "Professor Daubeny, M.D., F.R.S.". The Gentleman's Magazine. 224. Jan–May 1868. pp. 188–189.
- One or more of the preceding sentences incorporates text from a publication now in the public domain: Chisholm, Hugh, ed. (1911). "Daubeny, Charles Giles Bridle". Encyclopædia Britannica. 7 (11th ed.). Cambridge University Press. pp. 846–847.
- Daubeny, Charles (1826), A description of active and extinct volcanos : with remarks on their origin, their chemical phænomena, and the character of their products, as determined by the condition of the earth during the period of their formation : being the substance of some lectures delivered before the University of Oxford, with much additional matter, W. Phillips, retrieved 11 January 2016
- 'Edwards' Botanical Register' v21 (1835)
- "Review of Memoirs of the Life and Scientific Researches of John Dalton by William Charles Henry and An Introduction to the Atomic Theory by Charles Daubeny, 2nd edition". The London Quarterly Review: 24–40. January 1855.
- "Review of Lectures on Roman Husbandry by Charles Daubeny". The Quarterly Review. 104: 451–474. October 1858.