The son of Soviet historian Alexander Nove, his earliest presentational experience was at Glasgow's Hospital Broadcasting Service in 1976. From 1981 he was a member of BBC Radio 2's continuity team and, in common with many of the station's announcers and newsreaders, he had many stints presenting the station's overnight and early morning output, culminating as regular host of the weekend overnight show for several years until 1998. Nove has in the past served as a co-presenter and announcer on the original Come Dancing and announcer again for the gameshow Wipeout in the 1990s. In 1991 he commentated for BBC1 on the Lord Mayor's Show. He has also served as a BBC1 continuity announcer and, apart from his association with Radio 2, has presented radio programmes on Jazz FM, Magic FM and many others.
For several years, he was also the presenter of the EuroMix in-flight audio entertainment channel, exclusive to Emirates Airlines, showcasing artists such as Regy Clasen and Paola e Chiara. Long-haul passengers on BMI flights are guided through a special in-flight Yoga session presented by Nove on their Relaxation Channel. Nove has covered for regular National Lottery announcer Alan Dedicoat.
In recent years he has provided holiday relief for Radio 2 and what used to be Saga Radio in Scotland, and following John Marsh's retirement in February 2007 he became one of the regular newsreaders on the flagship breakfast show Wake Up to Wogan until its end in 2009. He was also the London studio technical operator when Terry Wogan presented his Radio 2 show from various locations around Europe during coverage of the Eurovision Song Contest and other outside broadcasts in the United Kingdom.
Nove is the co-owner of an AEC Routemaster bus, with Ken Bruce, Alan Dedicoat, Steve Madden and David Sheppard. On the Wogan show Nove was well known for his impersonation of Cyril "Blakey" Blake, the inspector from the 1970s television sitcom On the Buses.
Charles Nove founded the A1 VOX audio recording studios in London in 1999 and remains the company's Managing Director.
Since May 2011 Charles Nove has been a presenter on BBC Radio Oxford, where, until 2016, he presented the religious programme on Sundays between 6 and 9 am in addition to the Early Breakfast sequence on certain weekdays. Since Spring 2016 he has presented Early Breakfast Monday to Friday between 6 and 7 am, and then been a contributor to the main Breakfast Show.