Chondroitin ABC lyase
| Chondroitin ABC lyase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.2.4 | ||||||||
| CAS no. | 9024-13-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Chondroitin ABC lyase (EC 4.2.2.4, chondroitinase, chondroitin ABC eliminase, chondroitinase ABC) is an enzyme with systematic name chondroitin ABC lyase.[1][2] This enzyme catalyses the following chemical reaction
- Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups
This enzyme acts on chondroitin 4-sulfate, chondroitin 6-sulfate and dermatan sulfate.
Uses
Following a spinal cord injury, this enzyme can be used to erode scar tissue that can interfere with regeneration.[3]
References
- ^ Yamagata, T.; Saito, H.; Habuchi, O.; Suzuki, S. (1968). "Purification and properties of bacterial chondroitinases and chondrosulfatases". J. Biol. Chem. 243: 1523–1535. PMID 5647268.
- ^ Saito, H.; Yamagata, T.; Suzuki, S. (1968). "Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates". J. Biol. Chem. 243: 1536–1542. PMID 4231029.
- ^ https://www.eurekalert.org/pub_releases/2014-04/sfn-gti033114.php
External links
- Chondroitin+ABC+lyase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)