Christian Hartinger
Dr. Christian Hartinger | |
|---|---|
 Christian Hartinger | |
| Born | 1974 |
| Nationality | Austrian |
| Alma mater | University of Vienna (MSc, 1999; PhD, 2001; Habilitation, 2009) |
| Known for | |
| Awards | Carl Duisberg Memorial Prize (German Chemical Society) |
| Scientific career | |
| Fields | Chemistry |
| Institutions | The University of Auckland |
| Doctoral advisor | Bernhard Keppler |
| Website | hartinger |
Christian G. Hartinger (born 1974) is an Austrian-born New Zealand bioinorganic chemist known for his work in metal-based anticancer drugs.
Scientific career
Hartinger studied chemistry at the University of Vienna, earning his MSc in 1999 and his PhD in 2001 under Bernhard Keppler. He was an Erwin Schrödinger Fellow with Paul Dyson at the École Polytechnique Fédérale de Lausanne from 2006 to 2008 and obtained his habilitation at the University of Vienna in 2009. In 2011, Hartinger was appointed the position of Associate Professor at The University of Auckland, where he currently serves and in 2015 was promoted to Professor. He was also made deputy Head of School of Chemical Sciences in 2013.
Hartinger's research interests are in bioinorganic chemistry, medicinal chemistry, and bioanalytical chemistry, where he utilises an interdisciplinary approach in drug discovery. He is specially interested in the development of metal-centred anticancer agents, particularly ruthenium anticancer drugs, and using analytical methods to characterise their behaviour in the presence of biomolecules.[1]
Hartinger has now published over 150 publications and has an h-index of 48.[2]
Distinctions/honours
| Year | Distinction/honour | Organisation |
|---|---|---|
| 2005 | Theodor Körner Prize | Theodor Körner Fund |
| 2006 | Erwin Schrödinger Fellowship | Austrian Science Fund |
| 2009 | Best Paper Award for the publication Modifying the Structure of Dinuclear Ruthenium Complexes with Antitumor Activity[3] | Applied Organometallic Chemistry |
| 2010 | Innovative Teaching Award | Bank Austria |
| Visiting Professor | Chimie ParisTech, France | |
| 2011 | Carl Duisberg Memorial Prize | German Chemical Society |
| 2013 | Visiting Professor | University of Vienna |
| 2014 | Scientific Organizing Committee Co-chair | 7th International Symposium on Bioorganometallic Chemistry |
| 2016 | Chair of the 8th Asian Biological Inorganic Chemistry Conference | 8th Asian Biological Inorganic Chemistry (AsBIC) Conference |
| 2016 | SBIC Early Career Award 2016 | Society of Biological Inorganic Chemistry |
Selected research outputs
- Meier, S. M.; Novak, M. S.; Kandioller, W.; Jakupec, M. A.; Roller, A.; Keppler, B. K.; Hartinger, C. G., Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent. Dalton Trans, 2014, 43 (26), 9851-9855
- Meier, S. M.; Babak, M. V.; Keppler, B. K.; Hartinger, C. G., Efficiently detecting metallodrug-protein adducts: ion trap versus time-of-flight mass analyzers. ChemMedChem, 2014, 9 (7), 1351-1355
- Hartinger, C. G.; Groessl, M.; Meier, S. M.; Casini, A.; Dyson, P. J., Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs. Chem Soc Rev, 2013, 42 (14), 6186-6199
- Meier, S. M.; Novak, M.; Kandioller, W.; Jakupec, M. A.; Arion, V. B.; Metzler-Nolte, N.; Keppler, B. K.; Hartinger, C. G., Identification of the structural determinants for anticancer activity of a ruthenium arene peptide conjugate. Chem Eur J, 2013, 19 (28), 9297-9307
- Kandioller, W.; Balsano, E.; Meier, S. M.; Jungwirth, U.; Göschl S.; Roller, A.; Jakupec, M. A.; Berger, W.; Keppler, B. K.; Hartinger, C. G., Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity. Chem Commun, 2013, 49 (32), 3348-3350
- Meier, S. M.; Hanif, M.; Pichler, V.; Novak, M.; Jirkovsky, E.; Jakupec, M. A.; Davey, C. A.; Keppler, B. K.; Hartinger, C. G., Novel metal(II) arene 2-pyridinecarbothioamides: A rationale to orally active organometallic anticancer agents. Chem Sci, 2013, 4 (4), 1837-1846
- Babak, M. V.; Meier, S. M.; Legin, A. A.; Adib Razavi, M. S.; Roller, A.; Jakupec, M. A.; Keppler, B. K.; Hartinger, C. G., Am(m)ines make the difference: organoruthenium am(m)ine complexes and their chemistry in anticancer drug development. Chemistry, 2013, 19 (13), 4308-4318
- Kurzwernhart, A.; Kandioller, W.; Bächler S.; Bartel, C.; Martic, S.; Buczkowska, M.; Mühlgassner, G.; Jakupec, M. A.; Kraatz, H.; Berdnarski, P. J.; Arion, V .B.; Markos, D.; Keppler, B. K.; Hartinger, C. G., Structure-activity relationships of targeted RuII(η6-p-cymene) anticancer complexes with flavonol-derived ligands. J Med Chem, 2012, 55 (23), 10512-10522
References
- ^
Jakupec, M. A.; Galanski, M.; Arion, V. B.; Hartinger, C. G.; Keppler, B. K. (2008). "Antitumour metal compounds: more than theme and variations". Dalton Transactions (2): 183–194. doi:10.1039/b712656p.
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- ^
Mendoza-Ferri, M. G.; Hartinger, C. G.; Alexey, A. A.; Kandioller, W.; Severin, K.; Keppler, B. K. (2008). "Modifying the Structure of Dinuclear Ruthenium Complexes with Antitumor Activity". Applied Organometallic Chemistry. 22 (6): 326–332. doi:10.1002/aoc.1394.
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