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A comutagen is a substance that is not a mutagen by itself, but in the presence of a mutagen, enhances mutagenic activity. There are two manners in which this occur; the comutagen may strengthen the mutagenic response of mutagenic chemicals, or it can create a mutagenic response from nonmutagens. Chemicals such as harman and norharman (present in tobacco tar) have been identified as comutagens.
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- National Research Council (US) Committee on Diet, Nutrition, and Cancer (1982). Diet, Nutrition, and Cancer. National Academic Press.