D2HGDH

D2HGDH
Identifiers
Aliases	D2HGDH, D2HGD, D-2-hydroxyglutarate dehydrogenase
External IDs	OMIM: 609186; MGI: 2138209; HomoloGene: 5534; GeneCards: D2HGDH; OMA:D2HGDH - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	241,768,816 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	93,780,070 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; pancreatic ductal cell; ; tendon of biceps brachii; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; anterior pituitary; ; skin of abdomen; ; right lobe of liver; ; left ovary; ; transverse colon;
	Top expressed in
	left lobe of liver; ; otolith organ; ; utricle; ; interventricular septum; ; Rostral migratory stream; ; ascending aorta; ; hand; ; semi-lunar valve; ; Paneth cell; ; ciliary body;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; catalytic activity; flavin adenine dinucleotide binding; oxidoreductase activity, acting on CH-OH group of donors; D-lactate dehydrogenase (cytochrome) activity; (R)-2-hydroxyglutarate dehydrogenase activity; FAD binding;
Cellular component	mitochondrial matrix; mitochondrion; extrinsic component of cytoplasmic side of plasma membrane;
Biological process	response to calcium ion; response to zinc ion; response to magnesium ion; response to cobalt ion; response to manganese ion; 2-oxoglutarate metabolic process; lactate oxidation; respiratory electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	728294
	98314
	ENSG00000180902
	ENSMUSG00000073609
	Q8N465
	Q8CIM3
	NM_001287249; NM_152783; NM_001352824
	NM_178882; NM_001310767
	NP_001274178; NP_689996; NP_001339753
	NP_001297696; NP_849213
	Wikidata
View/Edit Human	View/Edit Mouse

D-2-hydroxyglutarate dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the D2HGDH gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180902 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000073609 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Achouri Y, Noel G, Vertommen D, Rider MH, Veiga-Da-Cunha M, Van Schaftingen E (Jun 2004). "Identification of a dehydrogenase acting on D-2-hydroxyglutarate". Biochem J. 381 (Pt 1): 35–42. doi:10.1042/BJ20031933. PMC 1133759. PMID 15070399.
^ Struys EA, Salomons GS, Achouri Y, Van Schaftingen E, Grosso S, Craigen WJ, Verhoeven NM, Jakobs C (Jan 2005). "Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria". Am J Hum Genet. 76 (2): 358–60. doi:10.1086/427890. PMC 1196381. PMID 15609246.
^ "Entrez Gene: D2HGDH D-2-hydroxyglutarate dehydrogenase".

D2HGDH

See also

References

Further reading