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Protein DEFB103A PDB 1kj6.png
Available structures
PDBHuman UniProt search: PDBe RCSB
AliasesDEFB103B, BD-3, DEFB-3, DEFB103, DEFB3, HBD-3, HBD3, HBP-3, HBP3, defensin beta 103B
External IDsOMIM: 606611 HomoloGene: 10256 GeneCards: DEFB103B
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for DEFB103B
Genomic location for DEFB103B
Band8p23.1Start7,428,888 bp[1]
End7,430,348 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 8: 7.43 – 7.43 Mbn/a
PubMed search[2]n/a
View/Edit Human

Beta-defensin 103 is a protein that in humans is encoded by the DEFB103A gene.[3][4][5]


Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103B, which has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense.[5]

In dogs, the product of the same genetic locus, β-Defensin 103, also plays a role in pigmentation, being an agonist of the melanocortin 1 receptor.[6]


  1. ^ a b c ENSG00000273641 GRCh38: Ensembl release 89: ENSG00000177243, ENSG00000273641 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Jia HP, Schutte BC, Schudy A, Linzmeier R, Guthmiller JM, Johnson GK, Tack BF, Mitros JP, Rosenthal A, Ganz T, McCray PB Jr (Mar 2001). "Discovery of new human beta-defensins using a genomics-based approach". Gene. 263 (1–2): 211–8. doi:10.1016/S0378-1119(00)00569-2. PMID 11223260.
  4. ^ Harder J, Bartels J, Christophers E, Schroder JM (Feb 2001). "Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic". J Biol Chem. 276 (8): 5707–13. doi:10.1074/jbc.M008557200. PMID 11085990.
  5. ^ a b "Entrez Gene: DEFB103A defensin, beta 103A".
  6. ^ Candille SI, Kaelin CB, Cattanach BM, Yu B, Thompson DA, Nix MA, Kerns JA, Schmutz SM, Millhauser GL, Barsh GS (November 2007). "A -defensin mutation causes black coat color in domestic dogs". Science. 318 (5855): 1418–23. doi:10.1126/science.1147880. PMC 2906624. PMID 17947548.

Further reading[edit]