DOCK (protein)

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1wg7

Dedicator of cytokinesis
Dedicator of cytokinesis
Identifiers
Symbol	Ded_cyto
Pfam	PF06920
InterPro	IPR010703
SCOP2	1wg7 / SCOPe / SUPFAM
CDD	cd11684
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1wg7

DOCK (Dedicator of cytokinesis) is a family of related proteins involved in intracellular signalling networks.^[1] Studies to date suggest that this family act as guanine nucleotide exchange factors for small G proteins of the Rho family, such as Rac and Cdc42. DOCK family proteins are categorised into four subfamilies based on their sequence homology:

DOCK-A subfamily
- Dock180 (also known as Dock1)
- Dock2
- Dock5
DOCK-B subfamily
- Dock3 (also known as MOCA and PBP)
- Dock4
DOCK-C subfamily (also known as Zir subfamily)
- Dock6 (also known as Zir1)
- Dock7 (also known as Zir2)
- Dock8 (also known as Zir3)
DOCK-D subfamily (also known as Zizimin subfamily)
- Dock9 (also known as Zizimin1)
- Dock10 (also known as Zizimin3)
- Dock11 (also known as Zizimin2)

References

^ Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". J. Cell. Sci. 115 (Pt 24): 4901–13. doi:10.1242/jcs.00219. PMID 12432077.

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