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DS2 may refer to:
- Dark Seed II, a 1995 adventure game
- Dark Souls II, a 2014 action role-playing video game
- Dead Space 2, a 2011 survival horror third-person shooter game
- Dungeon Siege II, a 2005 action role-playing game
- Darksiders II, a 2012 action role-playing hack and slash game
- SimCity DS 2, 2008 city-building game for the Nintendo DS
- DS2 (album), a 2015 album by American rapper Future
- C-Net DS2, a 1986 bulletin board system (BBS) for the Commodore 64 microcomputer
- Datsun DS-2, a 1951 car in the Datsun DS series
- DS-2, a type of Soviet satellite including Kosmos 1
| disambiguation page lists articles associated with the same title formed as a letter-number combination.
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