Daniel Ricquier

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Daniel Ricquier – December 2016

Daniel Ricquier (born 19 May 1949), is a French biochemist known for his work in mitochondria and hereditary metabolic diseases.[1] Ricquier has been a member of the French Academy of Sciences since 2002,[1] and a professor of biochemistry and Molecular Biology at the Faculty of Medicine of the University of Paris Descartes since 2003.[2]

Biography[edit]

Ricquier is a university professor and hospital practitioner at faculté́ of medicine at the University of Paris-Descartes, and at the Necker-Enfants malades Hospital,[3] since 2003.

He directed the "Centre de recherche sur l'endocrinologie moléculaire et le développement" of the CNRS in Meudon from 1997 to 2002, then the CNRS unit "Biologie des Transporteurs mitochondriaux et métabolisme" from 2002 to 2008 at faculté́ de médecine Necker Paris Descartes and at the Institut de recherches Necker-Enfants Malades. He was Head of the Metabolic Biochemistry Department at Necker Enfants Malades Hospital and at AP-HP from 2003 to 2014. He was elected a member of the Academy of Sciences on 19 November 2002.[1]

Works[edit]

Ricquier specializes in the physiology and biochemistry of mitochondria, adipose tissue and thermogenic mechanisms. He is an expert on brown adipose tissue. His work has contributed towards identifying a family of proteins involved in mitochondrial respiration, ATP yield, heat production and mitochondrial control of the level of cellular oxygenated free radicals.

Ricquier described in 1976 a mitochondrial membrane protein specific for brown adipocytes,[4] later named UCP (uncoupling protein) and identified by David Nicholls as the protein responsible for heat energy dissipation. Having isolated antibodies specific to this protein, he demonstrated brown adipocytes in neonates and adult patients and demonstrated that the sympathetic nervous system controls the development of brown adipose tissue and the synthesis of DCS in animals and humans.[5] With Fréderic Bouillaud, in 1984 and in collaboration with Jean Weissenbach at the Pasteur Institute, he isolated and sequenced the complementary DNA of the UCP and the UCP gene from rodents and humans.[6] He then analyzed the mechanisms of control of the tissue-specific transcription of the UCP gene. In addition, he studied the functional organization of this membrane protein.[7][8][9]

Ricquier identified and characterized in 1997 a second UCP protein called UCP2,[10] the brown adipocyte UCP being renamed UCP1. He also identified a new cerebral mitochondrial transporter, BMCP,[11] an avian UCP[12] and a renal mitochondrial transporter KMCP[13] and contributed to the identification of the first plant UCP protein.[14] He was able to obtain mice without the UCP2 gene, demonstrating the essential role of this gene in innate immunity and the limitation of free radical levels,[15][16][17] particularly in macrophages in collaboration with Denis Richard at Laval University. This function of UCP2 has been confirmed by the demonstration of a protective role of UCP2 against atherosclerosis.[18]

Ricquier has demonstrated that mutations in the UCP2 protein induce congenital hyperinsulinism in children at birth.[19] He also described a protective role for UCP2 against autoimmune diabetes.[20] Applications of the work include metabolic diseases (obesity, diabetes), nutrition, degenerative diseases and autoimmune diseases involving oxygenated free radicals in atherosclerosis and neurodegeneration.

Honours[edit]

  • 1988: Paul Langevin Prize from the French Academy of sciences
  • 1989: CNRS silver medal
  • 1995: F. Wasserman Medal of the European Association for the Study of Obesity[21]
  • 2000: Grand Prix des industries agro-alimentaires from the French Academy of sciences
  • 2002: Member of the French Academy of sciences[1]
  • 2002: Wertheimer Medal from the International Association of Study on Obesity
  • 2013: Chevalier in the Ordre de la Légion d'Honneur[22]
  • 2012–2017: Deputy Vice-president for International Relations of the French Academy of sciences[1]

References[edit]

  1. ^ a b c d e User, Super. "Daniel Ricquier | Liste des membres de l'Académie des sciences / R | Listes par ordre alphabétique | Listes des membres | Membres | Nous connaître". www.academie-sciences.fr (in French). Retrieved 2017-01-23. {{cite web}}: |last= has generic name (help)
  2. ^ Biomédicale, RIB UFR. "biochimie – [Faculté des Sciences Fondamentales et Biomédicales]". www.biomedicale.parisdescartes.fr (in French). Archived from the original on 2017-02-02. Retrieved 2017-01-23.
  3. ^ "Biochimie métabolomique et protéomique". Hôpital Necker-Enfants malades. 2016-10-17. Retrieved 2017-01-23.
  4. ^ Ricquier, D.; Kader, J. C. (1976). "Mitochondrial protein alteration in active brown fat: A soidum dodecyl sulfate-polyacrylamide gel electrophoretic study". Biochemical and Biophysical Research Communications. 73 (3): 577–83. doi:10.1016/0006-291x(76)90849-4. PMID 1008874.
  5. ^ Ricquier, D.; Nechad, M.; Mory, G. (1982). "Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma". The Journal of Clinical Endocrinology and Metabolism. 54 (4): 803–7. doi:10.1210/jcem-54-4-803. PMID 7061689.
  6. ^ Bouillaud, F.; Ricquier, D.; Thibault, J.; Weissenbach, J. (1985). "Molecular approach to thermogenesis in brown adipose tissue: CDNA cloning of the mitochondrial uncoupling protein". Proceedings of the National Academy of Sciences of the United States of America. 82 (2): 445–8. Bibcode:1985PNAS...82..445B. doi:10.1073/pnas.82.2.445. PMC 397055. PMID 3855564.
  7. ^ Cassard-Doulcier, A. M.; Gelly, C.; Fox, N.; Schrementi, J.; Raimbault, S.; Klaus, S.; Forest, C.; Bouillaud, F.; Ricquier, D. (1993). "Tissue-specific and beta-adrenergic regulation of the mitochondrial uncoupling protein gene: Control by cis-acting elements in the 5'-flanking region". Molecular Endocrinology. 7 (4): 497–506. doi:10.1210/mend.7.4.8388995. PMID 8388995.
  8. ^ Miroux, B.; Frossard, V.; Raimbault, S.; Ricquier, D.; Bouillaud, F. (1993). "The topology of the brown adipose tissue mitochondrial uncoupling protein determined with antibodies against its antigenic sites revealed by a library of fusion proteins". The EMBO Journal. 12 (10): 3739–45. doi:10.1002/j.1460-2075.1993.tb06051.x. PMC 413655. PMID 7691596.
  9. ^ Bouillaud, F.; Arechaga, I.; Petit, P. X.; Raimbault, S.; Levi-Meyrueis, C.; Casteilla, L.; Laurent, M.; Rial, E.; Ricquier, D. (1994). "A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of proton transport through the mitochondrial uncoupling protein". The EMBO Journal. 13 (8): 1990–7. doi:10.1002/j.1460-2075.1994.tb06468.x. PMC 395041. PMID 8168495.
  10. ^ Fleury, C.; Neverova, M.; Collins, S.; Raimbault, S.; Champigny, O.; Levi-Meyrueis, C.; Bouillaud, F.; Seldin, M. F.; Surwit, R. S.; Ricquier, D.; Warden, C. H. (1997). "Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia". Nature Genetics. 15 (3): 269–72. doi:10.1038/ng0397-269. PMID 9054939. S2CID 13421247.
  11. ^ Sanchis, D.; Fleury, C.; Chomiki, N.; Goubern, M.; Huang, Q.; Neverova, M.; Grégoire, F.; Easlick, J.; Raimbault, S.; Lévi-Meyrueis, C.; Miroux, B.; Collins, S.; Seldin, M.; Richard, D.; Warden, C.; Bouillaud, F.; Ricquier, D. (1998). "BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast". The Journal of Biological Chemistry. 273 (51): 34611–5. doi:10.1074/jbc.273.51.34611. PMID 9852133. S2CID 21178898.
  12. ^ Raimbault, S.; Dridi, S.; Denjean, F.; Lachuer, J.; Couplan, E.; Bouillaud, F.; Bordas, A.; Duchamp, C.; Taouis, M.; Ricquier, D. (2001). "An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds". The Biochemical Journal. 353 (Pt 3): 441–4. doi:10.1042/0264-6021:3530441. PMC 1221587. PMID 11171038.
  13. ^ Anne Haguenauer, Serge Raimbault, Sandrine Haguenauer, A.; Raimbault, S.; Masscheleyn, S.; Gonzalez-Barroso Mdel, M.; Criscuolo, F.; Plamondon, J.; Miroux, B.; Ricquier, D.; Richard, D.; Bouillaud, F.; Pecqueur, C. (2005). "A new renal mitochondrial carrier, KMCP1, is up-regulated during tubular cell regeneration and induction of antioxidant enzymes". The Journal of Biological Chemistry. 280 (23): 22036–43. doi:10.1074/jbc.M412136200. PMID 15809292. S2CID 1176549.
  14. ^ Laloi, M.; Klein, M.; Riesmeier, J. W.; Müller-Röber, B.; Fleury, C.; Bouillaud, F.; Ricquier, D. (1997). "A plant cold-induced uncoupling protein". Nature. 389 (6647): 135–6. Bibcode:1997Natur.389..135L. doi:10.1038/38156. PMID 9296489. S2CID 4360835.
  15. ^ Arsenijevic, D.; Onuma, H.; Pecqueur, C.; Raimbault, S.; Manning, B. S.; Miroux, B.; Couplan, E.; Alves-Guerra, M. C.; Goubern, M.; Surwit, R.; Bouillaud, F.; Richard, D.; Collins, S.; Ricquier, D. (2000). "Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production". Nature Genetics. 26 (4): 435–9. doi:10.1038/82565. PMID 11101840. S2CID 29831657.
  16. ^ Alves-Guerra, M. C.; Rousset, S.; Pecqueur, C.; Mallat, Z.; Blanc, J.; Tedgui, A.; Bouillaud, F.; Cassard-Doulcier, A. M.; Ricquier, D.; Miroux, B. (2003). "Bone marrow transplantation reveals the in vivo expression of the mitochondrial uncoupling protein 2 in immune and nonimmune cells during inflammation". The Journal of Biological Chemistry. 278 (43): 42307–12. doi:10.1074/jbc.M306951200. PMID 12907675. S2CID 23245867.
  17. ^ Emre, Y.; Hurtaud, C.; Nübel, T.; Criscuolo, F.; Ricquier, D.; Cassard-Doulcier, A. M. (2007). "Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages". The Biochemical Journal. 402 (2): 271–8. doi:10.1042/BJ20061430. PMC 1798432. PMID 17073824.
  18. ^ Blanc, J.; Alves-Guerra, M. C.; Esposito, B.; Rousset, S.; Gourdy, P.; Ricquier, D.; Tedgui, A.; Miroux, B.; Mallat, Z. (2003). "Protective role of uncoupling protein 2 in atherosclerosis". Circulation. 107 (3): 388–90. doi:10.1161/01.cir.0000051722.66074.60. PMID 12551860.
  19. ^ González-Barroso, M. M.; Giurgea, I.; Bouillaud, F.; Anedda, A.; Bellanné-Chantelot, C.; Hubert, L.; De Keyzer, Y.; De Lonlay, P.; Ricquier, D. (2008). "Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion". PLOS ONE. 3 (12): e3850. Bibcode:2008PLoSO...3.3850G. doi:10.1371/journal.pone.0003850. PMC 2588657. PMID 19065272.
  20. ^ Emre, Y.; Hurtaud, C.; Karaca, M.; Nubel, T.; Zavala, F.; Ricquier, D. (2007). "Role of uncoupling protein UCP2 in cell-mediated immunity: How macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes". Proceedings of the National Academy of Sciences of the United States of America. 104 (48): 19085–90. Bibcode:2007PNAS..10419085E. doi:10.1073/pnas.0709557104. PMC 2141912. PMID 18006654.
  21. ^ "EASO Award and Travel Grant Winners – 1995". easo.org. Archived from the original on 2017-02-02. Retrieved 2017-01-23.
  22. ^ Décret du 29 mars 2013  portant promotion et nomination
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