David Bailey (pharmacologist)

For other people named David Bailey, see David Bailey (disambiguation).

David Bailey

Medal record Men's Athletics Representing Canada Pan American Games 1967 Winnipeg 1.500 metres World University Games 1967 Tokyo 1.500 meteres

David ("Dave") Bailey (born March 17, 1945 in Toronto, Ontario) is a retired track and field athlete, who represented Canada at the 1968 Summer Olympics in the men's 1.500 metres. He was the first Canadian to run the mile in less than 4 minutes (3:59.1) in San Diego, CA on June 11, 1966 and the first Canadian to the run the mile in less than 4 minutes in Canada (3:57.7)in Toronto on July 22, 1967. A resident of Willowdale, Ontario he won the bronze medal in this event at the 1967 Pan American Games and the silver medal in this event at the 1968 World University Games He was two-time Canadian Universities Track and Field Athlete of Year (1965, 1967) and two-time inductee into the University of Toronto Sports Hall of Fame (individually 1998 and team 2003). He was a member of 9 Canadian National Track and Field Teams competing at World University Games, Budapest 1965 and Tokyo 1967, Commonwealth Games, Kingston, Jamaica, 1966, Pan American Games, Winnipeg, 1967, Commonwealth vs USA, Los Angeles, 1967, Pre-Olympic Games, Mexico City, 1967, Soviet Union Tour, 1968, European Tour, 1968, Olympic Games, Mexico City, 1968.

David Bailey completed undergraduate studies in Pharmacy (1968) and graduate work in Pharmacology (M.Sc. 1970; Ph.D. 1973) at the University of Toronto. After post-doctoral training in Pharmacology at the University of Saskatchewan and work in drug development for the pharmaceutical industry, he returned to academia in 1986 at the University of Western Ontario, Canada. He is currently full Professor in the Departments of Physiology & Pharmacology and Medicine. His research focused on mechanistic and translational clinical pharmacological investigations related to drug interactions.

Bailey notable publication of grapefruit – drug interactions (Lancet 1991; 337: 268-269) has been cited more than 300 times. Grapefruit decreased drug metabolism in humans, which likely represented the first clinical example of a food producing such an effect. Clinically, the concern is that a single judicious amount of grapefruit ingested even many hours beforehand would noticeably boost oral drug bioavailability and cause overdose toxicity. Research findings have demonstrated that grapefruit produced a clinically relevant interaction with more than 40 medications. Formal product information for a number of highly prescribed or essential medications now warn about the risk of a grapefruit - induced adverse drug interaction. A label stating, “Do NOT take with Grapefruit Juice” is often affixed to prescription vials.

Bailey's research was prominently discussed in such prestigious journals as Nature Medicine (Aronson JK, Forbidden Fruit. Nat Med 2001; 7: 29-30) and the New England Journal of Medicine (Wilkinson GR, Drug metabolism and variability among patients in drug response. N Eng J Med 2005; 352: 2211-21). A review article of his on the topic of grapefruit – drug interactions was republished in a special 2004 Anniversary Edition of the British Journal of Clinical Pharmacology, which reprinted only 14 publications that were considered of major importance over the past 30 years. A research study in the elderly received the William B Abrams Award from the American Society for Clinical Pharmacology & Therapeutics (1999). Dr. Bailey was the recipient of the Senior Investigator Award from the Canadian Society for Clinical Pharmacology (2005). Moreover, this research is now well known to the public through numerous articles in the lay press. Some were in the most influential and trusted publications including The New York Times (March 21, 2006), National Geographic (March 2007) and the Wall Street Journal (November 27, 2007). Thus, this research has received significant scientific, clinical and mainstream stature.

In recent years, Bailey has slightly shifted the focus of his research to assessing the effect of fruit juices on other potentially important mechanisms of drug absorption. Current research found that grapefruit and other juices (orange and apple) inhibited a specific intestinal drug uptake transporter (organic anion transporting polypeptide 1A2; OATP1A2) to diminish oral drug absorption discernibly in humans. The initial publication in 2002, which has been cited more than 100 times, supported a new model of intestinal drug absorption and novel mechanism of food-drug interactions. Most recently, he showed that the major flavonoid in grapefruit, naringin, was an important clinically active inhibitor of intestinal OATP1A2. This appeared to be the first example of a single dietary constituent modulating drug transport in humans.

References

• Canadian Olympic Committee