Difetarsone

Difetarsone
Clinical data
ATC code	P01AR02 (WHO) QP51AD02 (WHO);
Identifiers
	IUPAC name [4-[2-[(4-arsonophenyl)amino]ethylamino]phenyl] arsonic acid;
CAS Number	3639-19-8;
PubChem CID	68199;
ChemSpider	61506;
UNII	G4G9J3Q65W;
KEGG	D07357;
CompTox Dashboard (EPA)	DTXSID30189913 ;
ECHA InfoCard	100.020.788
Chemical and physical data
Formula	C14H18As2N2O6
Molar mass	460.146 g/mol g·mol−1

Difetarsone is an antiprotozoal agent. Various studies have shown it to be particularly effective against Trichuris trichiura, commonly known as the whipworm. Prior to the drugs use in the early 1970s, there were few effective treatments for this infection.^[1] It has also been used to treat Entamoeba histolytica infections.^[2]

Difetarsone often has minor side effects, which include rashes, nausea and vomiting. It has also resulted in angioedema in at least one known case.^[2]

References

^ P.M. Leary; C. Jones; F. Douglas; S.T. Boyd (June 1972). "Difetarsone in Difetarsone in outpatient treatment of Trichuris trichiura infestation". Archives of Disease in Childhood. 49 (6): 486–8. doi:10.1136/adc.49.6.486. PMC 1648795. PMID 4851370.
^ ^a ^b Jeffrey K. Aronson (2009). Meyler's Side Effects of Antimicrobial Drugs. p. 834. ISBN 9780080932934. Retrieved October 7, 2013.

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[1] P.M. Leary; C. Jones; F. Douglas; S.T. Boyd (June 1972). "Difetarsone in Difetarsone in outpatient treatment of Trichuris trichiura infestation". Archives of Disease in Childhood. 49 (6): 486–8. doi:10.1136/adc.49.6.486. PMC 1648795. PMID 4851370.

[meyler-2] Jeffrey K. Aronson (2009). Meyler's Side Effects of Antimicrobial Drugs. p. 834. ISBN 9780080932934. Retrieved October 7, 2013.

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