Diphtheria antitoxin

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Diphtheria antitoxin
Clinical data
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Routes of
administration
IM, IV
ATC code

Diphtheria antitoxin (DAT) is a medication made up of antibodies used in the treat of diphtheria.[1][2] It is no longer recommended for prevention of diphtheria.[2][3] It is given by injection into a vein or muscle.[2]

Side effects are common.[3] They include serum sickness and allergic reactions including anaphylaxis.[2] Diphtheria antitoxin is made from the blood plasma of horses that have been immunized against diphtheria toxin. It works by neutralizing the toxins produced by Corynebacterium diphtheriae.[1]

Diphtheria antitoxin was developed and came into medical use in the late 1800s.[4] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[5] In the United States it can be obtained from the Center for Disease Control.[1] It is not available in many countries including many in Europe as of 2008.[6]

Chemistry[edit]

It is a solution of concentrated proteins, chiefly globulins, containing antibodies obtained from the blood of horses that have been immunized against diphtheria toxin.[1]

References[edit]

  1. ^ a b c d "Our Formulary | Infectious Diseases Laboratories | CDC". www.cdc.gov. 22 September 2016. Retrieved 9 December 2016. 
  2. ^ a b c d WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 397. ISBN 9789241547659. Retrieved 8 January 2017. 
  3. ^ a b British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 850. ISBN 9780857111562. 
  4. ^ Hau, Jann; Schapiro, Steven J.; Jr, Gerald L. Van Hoosier (2004). Handbook of Laboratory Animal Science, Second Edition: Animal Models. CRC Press. p. 6. ISBN 9781420039627. 
  5. ^ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016. 
  6. ^ Wagner, KS; Stickings, P; White, JM; Neal, S; Crowcroft, NS; Sesardic, D; Efstratiou, A (10 December 2009). "A review of the international issues surrounding the availability and demand for diphtheria antitoxin for therapeutic use.". Vaccine. 28 (1): 14–20. PMID 19818425.