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Diphtheria antitoxin (DAT) is a medication made up of antibodies used in the treatment of diphtheria. It is no longer recommended for prevention of diphtheria. It is given by injection into a vein or muscle.
Side effects are common. They include serum sickness and allergic reactions including anaphylaxis. Diphtheria antitoxin is made from the blood plasma of horses that have been immunized against diphtheria toxin. It works by neutralizing the toxins produced by Corynebacterium diphtheriae.
Diphtheria antitoxin was developed and came into medical use in the late 1800s. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. In the United States it can be obtained from the Center for Disease Control. It is not available in many countries including many in Europe as of 2008.
- "Our Formulary | Infectious Diseases Laboratories | CDC". www.cdc.gov. 22 September 2016. Archived from the original on 16 December 2016. Retrieved 9 December 2016.
- World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 397. hdl:10665/44053. ISBN 9789241547659.
- British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 850. ISBN 9780857111562.
- Hau, Jann; Schapiro, Steven J.; Jr, Gerald L. Van Hoosier (2004). Handbook of Laboratory Animal Science, Second Edition: Animal Models. CRC Press. p. 6. ISBN 9781420039627. Archived from the original on 2017-09-23.
- World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- Wagner, KS; Stickings, P; White, JM; Neal, S; Crowcroft, NS; Sesardic, D; Efstratiou, A (10 December 2009). "A review of the international issues surrounding the availability and demand for diphtheria antitoxin for therapeutic use". Vaccine. 28 (1): 14–20. doi:10.1016/j.vaccine.2009.09.094. PMID 19818425.