Doi's sign

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Doi's sign is a clinical sign in which absent deep tendon reflexes can be elicited after a short period of maximal muscle contraction. This occurs in patients with Eaton-Lambert syndrome, but is not seen in patients with neuropathy.[1]

The sign is named after Dr. Hitoka M.D., who described it in 1978.[2]


  1. ^ Jane M. Orient, Joseph D. Sapira. Sapira's art & science of bedside diagnosis, 3rd edition, page 610. Google books
  2. ^ Doi, H; Murai Y; Kuroiwa Y (1978). "Deep tendon reflex in Eaton-Lambert syndrome". Folia Psychiatr Neurol Jpn. 32 (1): 109–13. doi:10.1111/j.1440-1819.1978.tb02784.x. PMID 207629.