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E500 can refer to:
- E number 500, a food additive
- Olympus E-500, a digital SLR camera
- Eclipse 500, a business jet aeroplane
- PowerPC e500, a microprocessor core from Freescale
- Sharp PC-E500S, a pocket computer by Sharp Corporation
- Mercedes-Benz E500, a luxury sports sedan automobile
- Alexander Dennis Enviro500, a tri-axle double-decker bus from Alexander Dennis
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