ENC1

ENC1
Identifiers
Aliases	ENC1, CCL28, ENC-1, KLHL35, KLHL37, NRPB, PIG10, TP53I10, ectodermal-neural cortex 1
External IDs	OMIM: 605173; MGI: 109610; HomoloGene: 2694; GeneCards: ENC1; OMA:ENC1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q13.3 Start 74,627,406 bp End 74,641,424 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 D1 Start 97,241,105 bp End 97,253,034 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 frontal pole middle temporal gyrus ganglionic eminence orbitofrontal cortex Brodmann area 46 superior frontal gyrus Region I of hippocampus proper ventricular zone parietal lobe Top expressed in barrel cortex medial ganglionic eminence subiculum anterior amygdaloid area olfactory tubercle prefrontal cortex lateral septal nucleus dorsal striatum dentate gyrus of hippocampal formation granule cell nucleus accumbens More reference expression data BioGPS n/a
Gene ontology Molecular function actin binding protein binding Cellular component cytoplasm nuclear matrix soma Cul3-RING ubiquitin ligase complex nucleolus cytoskeleton nucleus nucleoplasm Biological process multicellular organism development negative regulation of translation proteasomal ubiquitin-independent protein catabolic process protein ubiquitination nervous system development positive regulation of neuron projection development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8507 13803 Ensembl ENSG00000171617 ENSMUSG00000041773 UniProt O14682 O35709 RefSeq (mRNA) NM_001256574 NM_001256575 NM_001256576 NM_003633 NM_007930 RefSeq (protein) NP_001243503 NP_001243504 NP_001243505 NP_003624 NP_031956 Location (UCSC) Chr 5: 74.63 – 74.64 Mb Chr 13: 97.24 – 97.25 Mb PubMed search
Wikidata
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Ectoderm-neural cortex protein 1 is a protein that in humans is encoded by the ENC1 gene.

Function

DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.[supplied by OMIM]

Interactions

ENC1 has been shown to interact with Retinoblastoma protein.

Further reading

• Hernandez MC, Andres-Barquin PJ, Holt I, Israel MA (Aug 1998). "Cloning of human ENC-1 and evaluation of its expression and regulation in nervous system tumors". Experimental Cell Research. 242 (2): 470–7. doi:10.1006/excr.1998.4109. PMID 9683534.
• Hernandez MC, Andres-Barquin PJ, Kuo WL, Israel MA (2000). "Assignment of the ectodermal-neural cortex 1 gene (ENC1) to human chromosome band 5q13 by in situ hybridization". Cytogenetics and Cell Genetics. 87 (1–2): 89–90. doi:10.1159/000015398. PMID 10640818. S2CID 40487726.
• Zhao L, Gregoire F, Sul HS (Jun 2000). "Transient induction of ENC-1, a Kelch-related actin-binding protein, is required for adipocyte differentiation". The Journal of Biological Chemistry. 275 (22): 16845–50. doi:10.1074/jbc.275.22.16845. PMID 10828068.
• Kim TA, Ota S, Jiang S, Pasztor LM, White RA, Avraham S (Sep 2000). "Genomic organization, chromosomal localization and regulation of expression of the neuronal nuclear matrix protein NRP/B in human brain tumors". Gene. 255 (1): 105–16. doi:10.1016/S0378-1119(00)00297-3. PMID 10974570.
• Fujita M, Furukawa Y, Tsunoda T, Tanaka T, Ogawa M, Nakamura Y (Nov 2001). "Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas". Cancer Research. 61 (21): 7722–6. PMID 11691783.
• Hammarsund M, Lerner M, Zhu C, Merup M, Jansson M, Gahrton G, Kluin-Nelemans H, Einhorn S, Grandér D, Sangfelt O, Corcoran M (Dec 2004). "Disruption of a novel ectodermal neural cortex 1 antisense gene, ENC-1AS and identification of ENC-1 overexpression in hairy cell leukemia". Human Molecular Genetics. 13 (23): 2925–36. doi:10.1093/hmg/ddh315. PMID 15459180.
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (Mar 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Seng S, Avraham HK, Jiang S, Yang S, Sekine M, Kimelman N, Li H, Avraham S (Sep 2007). "The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells". Cancer Research. 67 (18): 8596–604. doi:10.1158/0008-5472.CAN-06-3785. PMID 17875699.