Jump to content

ERP29

From Wikipedia, the free encyclopedia
(Redirected from ERP29 (gene))
ERP29
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesERP29, C12orf8, ERp28, ERp31, HEL-S-107, PDI-DB, PDIA9, endoplasmic reticulum protein 29
External IDsOMIM: 602287; MGI: 1914647; HomoloGene: 4963; GeneCards: ERP29; OMA:ERP29 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006817
NM_001034025

NM_026129

RefSeq (protein)

NP_001029197
NP_006808

NP_080405

Location (UCSC)Chr 12: 112.01 – 112.02 MbChr 5: 121.57 – 121.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Endoplasmic reticulum protein 29 (ERp29) is a chaperone protein that in humans is encoded by the ERP29 gene.[5]

Function

[edit]

ERp29 is a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide-isomerase family.[6] However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase.[6] The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.[5]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000089248Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029616Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ERP29 endoplasmic reticulum protein 29".
  6. ^ a b Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (1): 6. doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.

Further reading

[edit]