Eccrine sweat gland
|Eccrine sweat gland|
A sectional view of the skin (magnified), with eccrine glands highlighted.
|Latin||Glandula sudorifera merocrina;
Glandula sudorifera eccrina
|Cholinergic sympathetic nerves|
Eccrine glands (//, //, or //; from ekkrinein "secrete"; sometimes called merocrine glands) are the major sweat glands of the human body, found in virtually all skin, with the highest density in palms and soles. They produce a clear, odorless substance, consisting primarily of water and NaCl. NaCl is reabsorbed in the duct to reduce salt loss, but is dysfunctional in cystic fibrosis thus producing salty sweat. They are active in thermoregulation by providing cooling from water evaporation of sweat secreted by the glands on the body surface and emotional induced sweating (anxiety, fear, stress, and pain). The white sediment in otherwise colorless eccrine secretions is caused by evaporation that increases the concentration of salts.
The odor from sweat is due to bacterial activity on the secretions of the apocrine sweat glands, a distinctly different type of sweat gland found in human skin.
Eccrine glands are composed of an intraepidermal spiral duct, the "acrosyringium"; a dermal duct, comprising a straight and coiled portion; and a secretory tubule, coiled deep in the dermis or hypodermis. Eccrine glands are innervated by the sympathetic nervous system, primarily by cholinergic fibers, but by adrenergic fibers as well.
The secretion of eccrine glands is a sterile, dilute electrolyte solution with primary components of bicarbonate, potassium, and sodium chloride (NaCl). There are other components secreted such as glucose, pyruvate, lactate, cytokines, immunoglobulins, antimicrobial peptides (e.g. dermcidin), and many others. Dermcidin is a newly isolated antimicrobial peptide produced by the eccrine sweat glands.
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