Dedini was born in King City, California, on June 29, 1921; his father was a dairy farmer, his mother a schoolteacher. He studied at Salinas Junior College, where Leon Amyx was on the teaching staff, and then at the Chouinard Art Institute in Los Angeles. There he met Virginia Conroy; they were married on July 15, 1944. They adopted a baby boy called john in 1960.
- Broccoli & Babes: The Cartoons and Posters of Eldon Dedini: November 4, 2005--January 20, 2006 at the Sasoontsi Gallery, Salinas, Calif.
- Monterey Museum of Art "Arriola, Dedini, Ketchum" 1982
He received the National Cartoonists Society's Gag Cartoon Award in 1958, 1961, 1964 and 1988.
- Illustrations for Bantam Books editions of Max Shulman works:
- Rally Round the Flag, Boys!, (1958) (1959)
- Barefoot Boy with Cheek (1959)
- Sleep Till Noon (1959)
- I Was a Teen-Age Dwarf (1960)
- The Feather Merchants
- Anyone Got a Match (1965)
- The Dedini Gallery. Holt, Rinehart and Winston, New York (1961)
- A Much, Much Better World. Microsoft Press, Bellevue WA (1985)
- Fantagraphics Books published a posthumous collection of his work, An Orgy of Playboy's Eldon Dedini (ISBN 1-56097-727-2) in 2006. Introduction by political cartoonist Dennis Renault. The book is bundled with a documentary "Dedini: A Life of Cartoons" by Anson Musselman.
- Robert C. Harvey (October 2008). Dedini, Eldon Lawrence (29 June 1921–12 January 2006). American National Biography. Oxford: Oxford University Press. doi:10.1093/anb/9780198606697.article.1701703. (subscription required)
- American National Biography Online
- New York Times report of death Retrieved January 14, 2006
- Monterey Herald obituary Retrieved January 14, 2006 (reprinted at emdashes.com
- "Broccoli and Babes," an article by Ben Bamsey in Artworks (winter 2005): 58-63
- Dedini's papers and original art are archived at the Cartoon Research Library at Ohio State University, which also has on file a videotape of his presentation at the 2001 Festival of Cartoon Art, sponsored by the Cartoon Research Library, during which Dedini showed slides of his cartoons and commented on them, offering a description of his working methods and attitudes.